Catalog No. size PriceQuantity
M6582-2 2mg solid $112
M6582-10 10mg solid $452



Product Information

SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), and has been shown to lower cholesterol levels in mice.


Chemical Formula: C26H27N3O2


Exact Mass: 413.2103


Molecular Weight: 413.52 


Elemental Analysis: C, 75.52; H, 6.58; N, 10.16; O, 7.74





SBC 110736



Chemical Name:



InChi Key:



InChi Code:  InChI=1S/C26H27N3O2/c1-19-8-14-24(15-9-19)28-16-17-29(25(18-28)21-6-4-3-5-7-21)26(31)22-10-12-23(13-11-22)27-20(2)30/h3-15,25H,16-18H2,1-2H3,(H,27,30)


Smiles Code:




Technical Data:


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:>2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


In Vivo

SBC-110736 (male C57BL/6 mice) lowers cholesterol levels in mice that were fed high fat diet, showing a mean of 38% reduction in total cholesterol levels after two weeks relative to high fat diet animal levels and a mean 50% reduction toward return to regular diet cholesterol levels.





  1. Sherin Salaheldin Abdel-Meguid, et al. Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases. WO2014150395A1.


Products are for research use only. Not for human use.


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