Madrasin


Catalog No. size PriceQuantity
M6590-2 2mg solid $101
M6590-10 10mg solid $411

Description

Cas:374913-63-0

Product Information

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.

 

Chemical Formula: C16H17N5O2

 

Exact Mass: 311.1382

 

Molecular Weight: 311.345

 

Elemental Analysis: C, 61.72; H, 5.50; N, 22.49; O, 10.28

 

Synonym: 

 

DDD00107587

Madrasin

RNA splicing inhibitor

 

Chemical Name:

2-((7-Methoxy-4-methylquinazolin-2-yl)amino)-5,6-dimethylpyrimidin-4(3H)-one

 

InChi Key:

QQJIYKXTEMDJFM-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)

 

Smiles Code:

O=C1NC(NC2=NC(C)=C3C=CC(OC)=CC3=N2)=NC(C)=C1C

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro

Madrasin (10-30 μM; 4-24 hours; HeLa cells) treatment inhibits the splicing of each of the RIOK3, BRD2, and Hsp40, MCL1, CCNA2, AURKA and p27 pre-mRNAs in both HeLa and HEK293 cells.

Madrasin (10-30 μM; 4-24 hours; HeLa and HEK293 cells) treatment shows a dose- and time-dependent inhibitory effect on cell cycle progression.

 

 

References

 

  1. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.

 

Products are for research use only. Not for human use.

 

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