GSK-872 is a receptor-interacting protein kinase-3 (RIP3) inhibitor. GSK-872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced by toll-like receptor 3 (TLR3).
Chemical Formula: C19H17N3O2S2
Exact Mass: 383.0762
Molecular Weight: 383.48
Elemental Analysis: C, 59.51; H, 4.47; N, 10.96; O, 8.34; S, 16.72
InChi Code: InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life:>2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
GSK-872 (GSK'872; 0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in human HT-29 cells in a concentration-dependent manner.
Liao L, Shang L, Li N, Wang S, Wang M, Huang Y, Chen D, Huang J, Xiong K. Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure. Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):879-889. doi: 10.1093/abbs/gmx088. PubMed PMID: 28981598.
Cekay MJ, Roesler S, Frank T, Knuth AK, Eckhardt I, Fulda S. Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines. Cancer Lett. 2017 Sep 18. pii: S0304-3835(17)30549-9. doi: 10.1016/j.canlet.2017.09.002. [Epub ahead of print] PubMed PMID: 28923396.
Lu B, Gong X, Wang ZQ, Ding Y, Wang C, Luo TF, Piao MH, Meng FK, Chi GF, Luo YN, Ge PF. Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation. Acta Pharmacol Sin. 2017 Aug 17. doi: 10.1038/aps.2017.112. [Epub ahead of print] PubMed PMID: 28816233.
Yang XS, Yi TL, Zhang S, Xu ZW, Yu ZQ, Sun HT, Yang C, Tu Y, Cheng SX. Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury. Sci Rep. 2017 Jul 19;7(1):5818. doi: 10.1038/s41598-017-06088-0. PubMed PMID: 28724891; PubMed Central PMCID: PMC5517428.
Bhatti IA, Abhari BA, Fulda S. Identification of a synergistic combination of Smac mimetic and Bortezomib to trigger cell death in B-cell non-Hodgkin lymphoma cells. Cancer Lett. 2017 Oct 1;405:63-72. doi: 10.1016/j.canlet.2017.07.008. Epub 2017 Jul 14. PubMed PMID: 28716527.
Products are for research use only. Not for human use.
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