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S-2238 is a chromogenic substrate for thrombin that is used in amidolytic assay.

Product information

CAS Number: 64815-81-2

Molecular Weight: 552.63

Formula: C27H36N8O5


S 2238


Related CAS Number:

160192-34-7 (hydrochloride)

62354-65-8 (dihydrochloride)

Chemical Name: N-(N2-(D-phenylalanyl)-N2-(4-nitrophenyl)-L-arginyl)piperidine-2-carboxamide

Smiles: NC(=N)NCCC[C@@H](C(=O)NC(=O)C1CCCCN1)N(C1C=CC(=CC=1)[N+]([O-])=O)C(=O)[C@H](N)CC1C=CC=CC=1


InChi: InChI=1S/C27H36N8O5/c28-21(17-18-7-2-1-3-8-18)26(38)34(19-11-13-20(14-12-19)35(39)40)23(10-6-16-32-27(29)30)25(37)33-24(36)22-9-4-5-15-31-22/h1-3,7-8,11-14,21-23,31H,4-6,9-10,15-17,28H2,(H4,29,30,32)(H,33,36,37)/t21-,22?,23+/m1/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200


  1. Fukuda C, Iijima K, Nakamura K. [Clinical evaluations of antithrombin III and alpha 2-plasmin inhibitor assay method with chromogenic substrates (S-2238, S-2251 (author's transl)]. Rinsho Byori. 1981 Feb;29(2):179-82. Japanese. PubMed PMID: 6453246.
  2. Girolami A, Patrassi G, Toffanin F, Saggin L. Chromogenic substrate (S-2238) prothrombin assay in prothrombin deficiencies and abnormalities. Lack of identity with clotting assays in congenital dysprothrombinemias. Am J Clin Pathol. 1980 Jul;74(1):83-7. PubMed PMID: 7395819.
  3. van Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984 Dec 29;52(3):350-3. PubMed PMID: 6531759.
  4. Goodnight SH Jr, Schaeffer JL, Sheth K. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980 May;73(5):639-47. PubMed PMID: 7377131.
  5. Tsuda T, Yoshimura H, Hamasaki N. Development of a new colorimetric method for protein S activity measurement. Clin Chem Lab Med. 2004 Mar;42(3):350-2. PubMed PMID: 15080571.

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