KL001 is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring a Bmal1-dLuc luciferase reporter). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In addition, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Therefore, KL001 serves as a useful tool to study the regulation of CRY-dependent physiology and may help development of clock-based therapeutics for treating diabetes.
CAS Number: 309928-48-1
Molecular Weight: 398.48
Chemical Name: N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-[(furan-2-yl)methyl]methanesulfonamide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
KL001 was used at 10-50 µM in vitro and in cellular assays.
- Hirota T, et al. Identification of Small Molecule Activators of Cryptochrome. (2012) Science 337(6098):1094-7.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.