LSD1-C76 is the most potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor reported to date. It inhibits LSD1 with an IC50 ~5 nM, but not monoamine oxidase proteins MAO-A and MAO-B (>5 µM). As LSD1 plays an important role in the epigenetic control of gene expression in normal development and cancer progression, LSD1-C76 serves as a very useful chemical probe to study the target biology.
CAS Number: 1235864-15-9
Molecular Weight: 295.38
Chemical Name: (1R,2S)-N-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)-2-phenylcyclopropanamine
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
LSD1-C76 was used at 1 µM in vitro.
- GUIBOURT, Nathalie, et al. Preparation of phenylcyclopropylamine derivatives as LSD1 selective and LSD1/MAO-B dual inhibitors in treating or preventing cancer. PCT WO/2010/084160.
- Shi Y, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. (2004) Cell. 119(7):941-53.
- Metzger E, et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. (2005) Nature. 437(7057):436-9.
Products are for research use only. Not for human use.
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