IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor


Catalog No. size PriceQuantity
M66054-2D 10 mM in DMSO (0.568 mL) $89
M66054-2S 2mg solid $89
M66054-10S 10 mg solid $365

Description

Product Information
Molecular Weight: 352.34
Formula: C19H16N2O5
Purity: ≥98%
CAS#: 931398-72-0
Solubility: DMSO up to 100 mM
Chemical Name: 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

IOX2 is a potent, selective and cell permeable inhibitor of hypoxia inducible factor 1α (HIF1α) prolyl hydroxylase-2 (PHD2). It inhibits PHD2 with an IC50 ~21 nM, and exhibits over 100-fold selectivity against JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM.

 

How to Use:

 

  •  In vitro:  IOX2 was usually used at 10-50µM final concentration in vitro
  •  In vivo: n/a

 

 

Reference:

 

  1. Murray JK, et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. (2010) J Comb Chem. 12(5):676-86.
  1. SGC website: http://www.thesgc.org/scientists/chemical_probes/IOX2
  1. Tian YM, et al. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. (2011) J Biol Chem. 286(15):13041-51.


Products are for research use only. Not for human use.

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