|Solubility:||DMSO up to 50 mM|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
Purmorphamine is a selective hedgehog pathway agonist that directly binds to and activates Smo receptor with an EC50 ~1 µM. It can promote the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. In recent publications, purmorphamine was used as a patterning (ventralizing) molecule in differentiating human ESCs/iPSC into dopaminergic or motor neurons.
How to Use:
- In vitro: Purmorphamine was used at 2-10 µM final concentration in cell culture.
- In vivo: n/a
- Wu X, et al. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. (2002) J Am Chem Soc 124, 14520-14521.
- Wu X, et al. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. (2004) Chem Biol 11 1229-1238.
- Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. (2005) Cell Biol Int 29(7) 537-541.
- Sinha S, et al. Purmorphamine activates the hedgehog pathway by targeting smoothened. (2006) Nat Chem Biol 2(1) 29-30.
- Kriks S, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. (2011) Nature 480, 547–551.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.