Purmorphamine, Hedgehog Agonist


Catalog No. Size PriceQuantity
M66055-5D 10 mM in DMSO (0.962 mL) $99
M66055-5S 5 mg solid $99
M66055-10S 10 mg solid $401

Description

Product Information
Molecular Weight: 520.62
Formula: C31H32N6O2
Purity: ≥98%
CAS#: 483367-10-8
Solubility: DMSO up to 50 mM
Chemical Name: 9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

 

Purmorphamine is a selective hedgehog pathway agonist that directly binds to and activates Smo receptor with an EC50 ~1 µM. It can promote the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. In recent publications, purmorphamine was used as a patterning (ventralizing) molecule in differentiating human ESCs/iPSC into dopaminergic or motor neurons.

 


How to Use:

 

 

  • In vitro: Purmorphamine was used at 2-10 µM final concentration in cell culture.
  • In vivo: n/a

 

 


Reference:

  1. Wu X, et al. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. (2002) J Am Chem Soc 124, 14520-14521.
  2. Wu X, et al. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. (2004) Chem Biol 11 1229-1238.
  3. Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. (2005) Cell Biol Int 29(7) 537-541.
  4. Sinha S, et al. Purmorphamine activates the hedgehog pathway by targeting smoothened. (2006) Nat Chem Biol 2(1) 29-30.
  5. Kriks S, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. (2011) Nature 480, 547–551.

Products are for research use only. Not for human use.

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