DAA1106

DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor.

Product information

CAS Number: 220551-92-8

Molecular Weight: 395.42

Formula: C23H22FNO4

Synonym:

DAA1106

DAA-1106

DAA 1106

Chemical Name:  N-[(2,5-dimethoxyphenyl)methyl]-N-(5-fluoro-2-phenoxyphenyl)acetamide

Smiles: CC(=O)N(CC1=CC(=CC=C1OC)OC)C1=CC(F)=CC=C1OC1C=CC=CC=1

InChiKey: DCRZYADKQRHHSF-UHFFFAOYSA-N

InChi: InChI=1S/C23H22FNO4/c1-16(26)25(15-17-13-20(27-2)10-12-22(17)28-3)21-14-18(24)9-11-23(21)29-19-7-5-4-6-8-19/h4-14H,15H2,1-3H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Kim T, Pae AN. Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1). Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. PubMed PMID: 27607364.
2. Shi H, Braun A, Wang L, Liang SH, Vasdev N, Ritter T. Synthesis of (18) F-Difluoromethylarenes from Aryl (Pseudo) Halides. Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10786-90. doi: 10.1002/anie.201604106. PubMed PMID: 27491349.
3. Zischler J, Krapf P, Richarz R, Zlatopolskiy BD, Neumaier B. Automated synthesis of 4-[(18)F]fluoroanisole, [(18)F]DAA1106 and 4-[(18)F]FPhe using Cu-mediated radiofluorination under "minimalist" conditions. Appl Radiat Isot. 2016 Sep;115:133-7. doi: 10.1016/j.apradiso.2016.04.030. PubMed PMID: 27372807.

Products are for research use only. Not for human use.