ZM306416


Catalog No. size PriceQuantity
M6617-2 2mg solid $88
M6617-10 10mg solid $360

Description

Cas:690206-97-4

Product Information:

ZM306416 is a vascular endothelial growth factor receptor (VEGFR) antagonist.

 

Chemical Formula: C16H13ClFN3O2

 

Exact Mass: 333.06803

 

Molecular Weight: 333.74

 

Elemental Analysis: C, 57.58; H, 3.93; Cl, 10.62; F, 5.69; N, 12.59; O, 9.59

 

Synonym: 

 

ZM306416

ZM 306416

ZM-306416

 

Chemical Name:

4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline

 

InChi Key:

YHUIUSRCUKUUQA-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)

 

Smiles Code: 

COC1=CC2=NC=NC(NC3=CC=C(Cl)C=C3F)=C2C=C1OC

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro

ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase.

 

 

References

 

  1. Antczak C, Mahida JP, Bhinder B, Calder PA, Djaballah H. A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99. doi: 10.1177/1087057112446174. Epub 2012 May 9. PubMed PMID: 22573732.

 

Products are for research use only. Not for human use.

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