Droxinostat

Cas：99873-43-5

Product Information：

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8. Droxinostat shows comparable inhibition of HDAC6 and HDAC8 (IC50 = 2.47 and 1.46 μmol/L, respectively).

Chemical Formula: C11H14ClNO3

Exact Mass: 243.06622

Molecular Weight: 243.68676

Elemental Analysis: C, 54.22; H, 5.79; Cl, 14.55; N, 5.75; O, 19.70

Synonym: 

NS 41080

4(4Chloro2methylphenoxy)Nhydroxybutanamide

NS41080

Chemical Name:

4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide

InChi Key:

JHSXDAWGLCZYSM-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)

Smiles Code:

O=C(NO)CCCOC1=CC=C(Cl)C=C1C

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

References：

1. Bijangi-Vishehsaraei K, Saadatzadeh MR, Huang S, Murphy MP, Safa AR. 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells. Mol Cell Biochem. 2010 Sep;342(1-2):133-42. Epub 2010 May 6. PubMed PMID: 20446019.

2. Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y, MacLean N, Ketela T, Reed JC, Moffat J, Minden MD,  Batey RA, Schimmer AD. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56. Epub 2010 Jan 6. PubMed PMID: 20053768.

Products are for research use only. Not for human use.