VU0357017 hydrochloride


Catalog No. size PriceQuantity
M6644-2 2mg solid $103
M6644-10 10mg solid $406

Description

Cas:1135242-13-5

Product Information:

VU0357017 hydrochloride , also known as CID 25010775, is a subtype-selective M1 muscarinic acetylcholine allosteric agonist.

 

Chemical Formula: C18H28ClN3O3

 

Molecular Weight: 369.89

 

Elemental Analysis: C, 58.45; H, 7.63; Cl, 9.58; N, 11.36; O, 12.98

 

Synonym:

 

VU0357017

VU-0357017

VU 0357017

CID 25010775

CID25010775

CID-25010775

 

Chemical Name: 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester, monohydrochloride

 

InChi Key: 

XKJQVUIXSBOCPP-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H

 

Smiles Code:

O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC.[H]Cl

 

 

Technical Data:

 

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Jadeja RN, Urrunaga NH, Ahmad D, Khurana S. Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress. Data Brief. 2015 Dec 18;6:405-9. doi: 10.1016/j.dib.2015.12.025. PubMed PMID: 26862589; PubMed Central PMCID: PMC4707288.

 

  1. Digby GJ, Utley TJ, Lamsal A, Sevel C, Sheffler DJ, Lebois EP, Bridges TM, Wood MR, Niswender CM, Lindsley CW, Conn PJ. Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36. doi: 10.1021/cn300103e. PubMed PMID: 23259038; PubMed Central PMCID: PMC3526969.

 

  1. Sheffler DJ, Sevel C, Le U, Lovell KM, Tarr JC, Carrington SJ, Cho HP, Digby GJ, Niswender CM, Conn PJ, Hopkins CR, Wood MR, Lindsley CW. Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorg Med Chem Lett. 2013 Jan 1;23(1):223-7. doi: 10.1016/j.bmcl.2012.10.132. PubMed PMID: 23200253; PubMed Central PMCID: PMC3525729.

 

  1. Digby GJ, Noetzel MJ, Bubser M, Utley TJ, Walker AG, Byun NE, Lebois EP, Xiang Z, Sheffler DJ, Cho HP, Davis AA, Nemirovsky NE, Mennenga SE, Camp BW, Bimonte-Nelson HA, Bode J, Italiano K, Morrison R, Daniels JS, Niswender CM, Olive MF, Lindsley CW, Jones CK, Conn PJ. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. J Neurosci. 2012 Jun 20;32(25):8532-44. doi: 10.1523/JNEUROSCI.0337-12.2012. PubMed PMID: 22723693; PubMed Central PMCID: PMC3398407.

 

  1. Thomsen M, Lindsley CW, Conn PJ, Wessell JE, Fulton BS, Wess J, Caine SB. Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice. Psychopharmacology (Berl). 2012 Apr;220(4):673-85. doi: 10.1007/s00213-011-2516-9. PubMed PMID: 21964721; PubMed Central PMCID: PMC3314162.

 

Products are for research use only. Not for human use.

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