FIN56

FIN56 is a specific inducer of ferroptosis.

Product information

CAS Number: 1083162-61-1

Molecular Weight: 517.66

Formula: C25H31N3O5S2

Synonym:

FIN-56

FIN56

FIN 56

Chemical Name:  N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

Smiles: ON=C1C2=CC(=CC=C2C2=CC=C(C=C21)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1

InChiKey: JLCFMMIWBSZOIS-UHFFFAOYSA-N

InChi: InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

FIN56 (5 μM) can trigger ferroptosis by inhibition of glutathione peroxidase 4 (GPX4). FIN56 (5 μM, 10 hours) depletes GPX4 protein in HT-1080 cells.

References:

1. Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503. doi: 10.1038/nchembio.2079. Epub 2016 May 9. PubMed PMID: 27159577; PubMed Central PMCID: PMC4920070.
2. Kolasa A. [Epididymis in an experimental model of DHT deficiency: immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies]. Ann Acad Med Stetin. 2006;52(2):13-21; discussion 21. Polish. PubMed PMID: 17633123.

Products are for research use only. Not for human use.