CNQX


Catalog No. size PriceQuantity
M6653-2 2mg solid $143
M6653-10 10mg solid $577

Description

Cas:115066-14-3 (free acid)

         479347-85-8 (sodium)

Product Information

CNQX is a water-soluble form of AMPA/kainate antagonist CNQX.

 

Chemical Formula: C9H2N4Na2O4

 

Exact Mass: 275.9871

 

Molecular Weight: 276.11

 

Elemental Analysis: C, 39.15; H, 0.73; N, 20.29; Na, 16.65; O, 23.18

 

Synonym: 

 

CNQX Disodium

CNQX 2Na

 

Chemical Name:  

sodium 6-cyano-7-nitroquinoxaline-2,3-bis(olate)

 

InChi Key:

YCXDDPGRZKUGDG-UHFFFAOYSA-L

 

InChi Code:   InChI=1S/C9H4N4O4.2Na/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;/h1-2H,(H,11,14)(H,12,15);;/q;2*+1/p-2

 

Smiles Code:

N#CC1=C([N+]([O-])=O)C=C2N=C([O-])C([O-])=NC2=C1.[Na+].[Na+]

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

 

In Vitro

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.

CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.

 

In Vivo

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.

CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.

 

 

References

 

  1. Sergeeva OA, De Luca R, Mazur K, Chepkova AN, Haas HL, Bauer A. N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Neuropharmacology. 2017 Jun;119:111-122. doi: 10.1016/j.neuropharm.2017.04.011. Epub 2017 Apr 9. PubMed PMID: 28400256.

 

  1. Blasiak A, Siwiec M, Grabowiecka A, Blasiak T, Czerw A, Blasiak E, Kania A, Rajfur Z, Lewandowski MH, Gundlach AL. Excitatory orexinergic innervation of rat nucleus incertus--Implications for ascending arousal, motivation and feeding control. Neuropharmacology. 2015 Dec;99:432-47. doi: 10.1016/j.neuropharm.2015.08.014. Epub 2015 Aug 8. PubMed PMID: 26265304.

 

  1. Zagrean AM, Spataru A, CeangaM, Zagrean L. The single versus combinatorial effects of MK-801, CNQX, Nifedipine and AP-3 on primary cultures of cerebellar granule cells in an oxygen-glucose deprivation model. Rom J Morphol Embryol. 2014;55(3):811-6. PubMed PMID: 25329107.

 

  1. Gigout S, Louvel J, Rinaldi D, Martin B, Pumain R. Thalamocortical relationships and network synchronization in a new genetic model "in mirror" for absence epilepsy. Brain Res. 2013 Aug 7;1525:39-52. doi: 10.1016/j.brainres.2013.05.044. Epub 2013 Jun 3. PubMed PMID: 23743261.

 

  1. Ferreira-Neto HC, Yao ST, Antunes VR. Purinergic and glutamatergic interactions in the hypothalamic paraventricular nucleus modulate sympathetic outflow. Purinergic Signal. 2013 Sep;9(3):337-49. doi: 10.1007/s11302-013-9352-9. Epub 2013 Feb 12. PubMed PMID: 23400372; PubMed Central PMCID: PMC3757145.

 

Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed