DNQX

Cas：2379-57-9

Product Information：

DNQX is a competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Chemical Formula: C8H4N4O6 

Exact Mass: 252.0131 

Molecular Weight: 252.142 

Elemental Analysis: C, 38.11; H, 1.60; N, 22.22; O, 38.07

Synonym: 

dnqx

2379-57-9

6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione

FG 9041

FG-9041

UNII-62T278S1MX

6,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione

6,7-Dinitroquinoxaline-2,3-dione (DNQX)

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-

62T278S1MX

SR-01000075442

1ftl

Tocris-0189

Lopac-D-0540

Biomol-NT_000182

Lopac0_000345

Oprea1_127694

MLS000705107

SCHEMBL594575

BPBio1_001176

C8H4N4O6

CHEMBL155265

SCHEMBL8128055

CHEBI:93492

CTK8F7031

DTXSID60178476

6,7-dinitro-2,3-quinoxalinediol

6,7-dinitroquinoxaline-2,3-diol

HMS2599K21

HMS3261E11

HMS3266C03

HMS3411A15

HMS3675A15

BCP34647

DNQX, >=98% (TLC)

ox21_500345

MFCD00069257

STL431184

STL507389

ZINC18118278

AKOS000448016

AKOS005066561

CCG-204440

CS-5935

DB03759

LP00345

MCULE-3076221110

SDCCGSBI-0050333.P002

NCGC00015319-01

NCGC00015319-02

NCGC00015319-03

NCGC00015319-04

NCGC00015319-05

NCGC00015319-06

NCGC00015319-13

NCGC00024490-01

NCGC00024490-02

NCGC00024490-03

NCGC00024490-04

NCGC00261030-01

AS-55799

HY-15067

SMR000230466

ST044512

LS-143032

EU-0100345

FT-0620868

NS00071564

KS-00001876

A13882

D 0540

FG 9041;FG9041;FG-9041

1,4-Dihydro-6,7-Dinitro-2,3-Quinoxalinedione

AE-641/00586054

SR-01000313889

J-015214

SR-01000075442-1

SR-01000075442-3

SR-01000313889-1

BRD-K64400208-001-01-8

BRD-K64400208-001-02-6

BRD-K85266041-304-01-7

Chemical Name:

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

InChi Key:

RWVIMCIPOAXUDG-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

Smiles Code:

O=C1NC2=C(C=C([N+]([O-])=O)C([N+]([O-])=O)=C2)NC1=O

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

In Vitro：

DNQX selectively depolarizes thalamic reticular nucleus (TRN) neurons.

In Vivo：

DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminished PCP (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex.

References：

1. Gwynne RM, Ly KDKN, Parry LJ, Bornstein JC. Calcium Sensing Receptors Mediate Local Inhibitory Reflexes Evoked by L-Phenylalanine in Guinea Pig Jejunum. Front Physiol. 2017 Dec 4;8:991. doi: 10.3389/fphys.2017.00991. eCollection 2017. PubMed PMID: 29255423; PubMed Central PMCID: PMC5722837.

2. Zeng Z, Wang D, Gaur U, Rifang L, Wang H, Zheng W. H(2)O(2) attenuates IGF-1R tyrosine phosphorylation and its survival signaling properties in neuronal cells via NR2B containing NMDA receptor. Oncotarget. 2017 Jun 27;8(39):65313-65328. doi: 10.18632/oncotarget.18625. eCollection 2017 Sep 12. PubMed PMID: 29029433; PubMed Central PMCID: PMC5630333.

3. de Freitas GRS, Coelho SE, Monteiro NKV, Neri JM, Cavalcanti LN, Domingos JB, Vieira DS, de Souza MAF, Menezes FG. Theoretical and Experimental Investigation of Acidity of the Glutamate Receptor Antagonist 6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione and Its Possible Implication in GluA2 Binding. J Phys Chem A. 2017 Oct 5;121(39):7414-7423. doi: 10.1021/acs.jpca.7b07775. Epub 2017 Sep 25. PubMed PMID: 28902515.

4. Demmer CS, Rombach D, Liu N, Nielsen B, Pickering DS, Bunch L. Revisiting the Quinoxalinedione Scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors. ACS Chem Neurosci. 2017 Nov 15;8(11):2477-2495. doi: 10.1021/acschemneuro.7b00243. Epub 2017 Sep 5. PubMed PMID: 28872835.

5. Gonçalves FM, Neis VB, Rieger DK, Peres TV, Lopes MW, Heinrich IA, Costa AP, Rodrigues ALS, Kaster MP, Leal RB. Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test. J Neural Transm (Vienna). 2017 Oct;124(10):1227-1237. doi: 10.1007/s00702-017-1753-4. Epub 2017 Jul 10. PubMed PMID: 28695335.

Products are for research use only. Not for human use.