Description
Cas:2379-57-9
Product Information:
DNQX is a competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.
Chemical Formula: C8H4N4O6
Exact Mass: 252.0131
Molecular Weight: 252.142
Elemental Analysis: C, 38.11; H, 1.60; N, 22.22; O, 38.07
Synonym:
dnqx
2379-57-9
6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione
FG 9041
FG-9041
UNII-62T278S1MX
6,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione
6,7-Dinitroquinoxaline-2,3-dione (DNQX)
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-
62T278S1MX
SR-01000075442
1ftl
Tocris-0189
Lopac-D-0540
Biomol-NT_000182
Lopac0_000345
Oprea1_127694
MLS000705107
SCHEMBL594575
BPBio1_001176
C8H4N4O6
CHEMBL155265
SCHEMBL8128055
CHEBI:93492
CTK8F7031
DTXSID60178476
6,7-dinitro-2,3-quinoxalinediol
6,7-dinitroquinoxaline-2,3-diol
HMS2599K21
HMS3261E11
HMS3266C03
HMS3411A15
HMS3675A15
BCP34647
DNQX, >=98% (TLC)
ox21_500345
MFCD00069257
STL431184
STL507389
ZINC18118278
AKOS000448016
AKOS005066561
CCG-204440
CS-5935
DB03759
LP00345
MCULE-3076221110
SDCCGSBI-0050333.P002
NCGC00015319-01
NCGC00015319-02
NCGC00015319-03
NCGC00015319-04
NCGC00015319-05
NCGC00015319-06
NCGC00015319-13
NCGC00024490-01
NCGC00024490-02
NCGC00024490-03
NCGC00024490-04
NCGC00261030-01
AS-55799
HY-15067
SMR000230466
ST044512
LS-143032
EU-0100345
FT-0620868
NS00071564
KS-00001876
A13882
D 0540
FG 9041;FG9041;FG-9041
1,4-Dihydro-6,7-Dinitro-2,3-Quinoxalinedione
AE-641/00586054
SR-01000313889
J-015214
SR-01000075442-1
SR-01000075442-3
SR-01000313889-1
BRD-K64400208-001-01-8
BRD-K64400208-001-02-6
BRD-K85266041-304-01-7
Chemical Name:
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
InChi Key:
RWVIMCIPOAXUDG-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
Smiles Code:
O=C1NC2=C(C=C([N+]([O-])=O)C([N+]([O-])=O)=C2)NC1=O
Technical Data:
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
In Vitro:
DNQX selectively depolarizes thalamic reticular nucleus (TRN) neurons.
In Vivo:
DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminished PCP (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex.
References:
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Gwynne RM, Ly KDKN, Parry LJ, Bornstein JC. Calcium Sensing Receptors Mediate Local Inhibitory Reflexes Evoked by L-Phenylalanine in Guinea Pig Jejunum. Front Physiol. 2017 Dec 4;8:991. doi: 10.3389/fphys.2017.00991. eCollection 2017. PubMed PMID: 29255423; PubMed Central PMCID: PMC5722837.
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Zeng Z, Wang D, Gaur U, Rifang L, Wang H, Zheng W. H(2)O(2) attenuates IGF-1R tyrosine phosphorylation and its survival signaling properties in neuronal cells via NR2B containing NMDA receptor. Oncotarget. 2017 Jun 27;8(39):65313-65328. doi: 10.18632/oncotarget.18625. eCollection 2017 Sep 12. PubMed PMID: 29029433; PubMed Central PMCID: PMC5630333.
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de Freitas GRS, Coelho SE, Monteiro NKV, Neri JM, Cavalcanti LN, Domingos JB, Vieira DS, de Souza MAF, Menezes FG. Theoretical and Experimental Investigation of Acidity of the Glutamate Receptor Antagonist 6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione and Its Possible Implication in GluA2 Binding. J Phys Chem A. 2017 Oct 5;121(39):7414-7423. doi: 10.1021/acs.jpca.7b07775. Epub 2017 Sep 25. PubMed PMID: 28902515.
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Demmer CS, Rombach D, Liu N, Nielsen B, Pickering DS, Bunch L. Revisiting the Quinoxalinedione Scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors. ACS Chem Neurosci. 2017 Nov 15;8(11):2477-2495. doi: 10.1021/acschemneuro.7b00243. Epub 2017 Sep 5. PubMed PMID: 28872835.
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Gonçalves FM, Neis VB, Rieger DK, Peres TV, Lopes MW, Heinrich IA, Costa AP, Rodrigues ALS, Kaster MP, Leal RB. Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test. J Neural Transm (Vienna). 2017 Oct;124(10):1227-1237. doi: 10.1007/s00702-017-1753-4. Epub 2017 Jul 10. PubMed PMID: 28695335.
Products are for research use only. Not for human use.
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