DNQX

DNQX is a competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Product information

CAS Number: 2379-57-9

Molecular Weight: 252.14

Formula: C8H4N4O6

Synonym:

dnqx

FG-9041

UNII-62T278S1MX

SR-01000075442

Lopac-D-0540

2379-57-9

6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione

FG 9041

6,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione

6,7-Dinitroquinoxaline-2,3-dione (DNQX)

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-

62T278S1MX

1ftl

Tocris-0189

Biomol-NT_000182

Lopac0_000345

Oprea1_127694

MLS000705107

SCHEMBL594575

BPBio1_001176

C8H4N4O6

CHEMBL155265

SCHEMBL8128055

Chemical Name: 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

Smiles: [O-][N+](=O)C1=CC2NC(=O)C(=O)NC=2C=C1[N+]([O-])=O

InChiKey: RWVIMCIPOAXUDG-UHFFFAOYSA-N

InChi: InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

DNQX selectively depolarizes thalamic reticular nucleus (TRN) neurons.

In Vivo:

DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminished PCP (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex.

References:

1. Gwynne RM, Ly KDKN, Parry LJ, Bornstein JC. Calcium Sensing Receptors Mediate Local Inhibitory Reflexes Evoked by L-Phenylalanine in Guinea Pig Jejunum. Front Physiol. 2017 Dec 4;8:991. doi: 10.3389/fphys.2017.00991. eCollection 2017. PubMed PMID: 29255423; PubMed Central PMCID: PMC5722837.
2. Zeng Z, Wang D, Gaur U, Rifang L, Wang H, Zheng W. H(2)O(2) attenuates IGF-1R tyrosine phosphorylation and its survival signaling properties in neuronal cells via NR2B containing NMDA receptor. Oncotarget. 2017 Jun 27;8(39):65313-65328. doi: 10.18632/oncotarget.18625. eCollection 2017 Sep 12. PubMed PMID: 29029433; PubMed Central PMCID: PMC5630333.
3. Demmer CS, Rombach D, Liu N, Nielsen B, Pickering DS, Bunch L. Revisiting the Quinoxalinedione Scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors. ACS Chem Neurosci. 2017 Nov 15;8(11):2477-2495. doi: 10.1021/acschemneuro.7b00243. Epub 2017 Sep 5. PubMed PMID: 28872835.

Products are for research use only. Not for human use.