L006235


Catalog No. size PriceQuantity
M6669-2 2mg solid $128
M6669-10 10mg solid $522

Description

Cas:294623-49-7

Product Information

L006235, also called L235, is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S.

 

Chemical Formula: C24H30N6O2S

 

Exact Mass: 466.21509

 

Molecular Weight: 466.6

 

Elemental Analysis: C, 61.78; H, 6.48; N, 18.01; O, 6.86; S, 6.87

 

Synonym: 

 

L006235

L 006235

L-006235

L235

L-235

L 235

 

Chemical Name:

N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamide

 

InChi Key:

FIVYCSWOCXEWSE-UHFFFAOYSA-N

 

InChi Code:

InChI=1S/C24H30N6O2S/c1-29-13-15-30(16-14-29)23-27-20(17-33-23)18-5-7-19(8-6-18)21(31)28-24(9-3-2-4-10-24)22(32)26-12-11-25/h5-8,17H,2-4,9-10,12-16H2,1H3,(H,26,32)(H,28,31)

 

Smiles Code:

O=C(NC1(C(NCC#N)=O)CCCCC1)C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Nwosu LN, Gowler PRW, Burston JJ, Rizoska B, Tunblad K, Lindström E, Grabowska U, Li L, McWilliams DF, Walsh DA, Chapman V. Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain. Pain Rep. 2018 Oct 5;3(6):e685. doi: 10.1097/PR9.0000000000000685. PMID: 30706033; PMCID: PMC6344135.

 

  1. Yu NY, Fathi A, Murphy CM, Mikulec K, Peacock L, Cantrill LC, Dehghani F, Little DG, Schindeler A. Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(d,l-lactide-co-glycolide) nanospheres. J Biomed Mater Res B Appl Biomater. 2017 Jan;105(1):136-144. doi: 10.1002/jbm.b.33481. Epub 2015 Oct 5. PMID: 26435360.

 

  1. Pennypacker BL, Oballa RM, Levesque S, Kimmel DB, Duong LT. Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits. BMC Musculoskelet Disord. 2013 Dec 9;14:344. doi: 10.1186/1471-2474-14-344. PMID: 24321244; PMCID: PMC3878918.

 

  1. Soung do Y, Gentile MA, Duong LT, Drissi H. Effects of pharmacological inhibition of cathepsin K on fracture repair in mice. Bone. 2013 Jul;55(1):248-55. doi: 10.1016/j.bone.2013.02.010. Epub 2013 Feb 26. PMID: 23486186.

 

  1. Hayami T, Zhuo Y, Wesolowski GA, Pickarski M, Duong LT. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone. 2012 Jun;50(6):1250-9. doi: 10.1016/j.bone.2012.03.025. Epub 2012 Mar 30. PMID: 22484689.

 

Products are for research use only. Not for human use.

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