RIP2 kinase inhibitor 1


Catalog No. size PriceQuantity
M6670-2 2mg solid $114
M6670-10 10mg solid $441

Description

Cas:1423186-80-4

Product Information

RIP2 kinase inhibitor 1 is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase.

 

Chemical Formula: C21H22N4O4S2

 

Exact Mass: 458.1082

 

Molecular Weight: 458.55

 

Elemental Analysis: C, 55.01; H, 4.84; N, 12.22; O, 13.96; S, 13.98

 

Synonym: 

 

GSK2983559-AM

GSK2983559-active metabolite

GSK2983559

GSK-2983559  

GSK 2983559  

RIPK2-IN-1

RIPK2 IN 1

RIPK2IN1

RIPK2 inhibitor-1

RIPK2 inhibitor 1

 

Chemical Name:

2-[[4-(5-Benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]ethanol

 

InChi Key:

UHDOJINBFLDQJM-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C21H22N4O4S2/c1-21(2,3)31(27,28)19-9-14-15(10-17(19)29-7-6-26)22-11-23-20(14)25-13-4-5-18-16(8-13)24-12-30-18/h4-5,8-12,26H,6-7H2,1-3H3,(H,22,23,25)

 

Smiles Code:

O=S(C1=CC2=C(NC3=CC=C(SC=N4)C4=C3)N=CN=C2C=C1OCCO)(C(C)(C)C)=O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro

RIP2 kinase inhibitor 1 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide.

 

 

References

 

  1. Sheridan C. Publisher Correction: Death by inflammation: drug makers chase the master controller. Nat Biotechnol. 2019;37(4):480. doi:10.1038/s41587-019-0082-6.

 

Products are for research use only. Not for human use.

 

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