NSC-348884

NSC-348884 is a nucleophosmin inhibitor. NSC-348884 also disrupts oligomer formation and induces apoptosis in human cancer cells.

Product information

CAS Number: 81624-55-7

Molecular Weight: 636.79

Formula: C38H40N10

Synonym:

NSC 348884

NSC348884

NSC-348884

Chemical Name: N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine

Smiles: CC1=CC2NC(CN(CC3NC4=CC(C)=CC=C4N=3)CCN(CC3NC4=CC(C)=CC=C4N=3)CC3NC4=CC(C)=CC=C4N=3)=NC=2C=C1

InChiKey: KZOLQEUQAFTQFM-UHFFFAOYSA-N

InChi: InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Zhang J, Zhao HL, He JF, Li HY. [Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Feb;34(1):58-61. Chinese. PubMed PMID: 22737721.
2. Qi W, Shakalya K, Stejskal A, Goldman A, Beeck S, Cooke L, Mahadevan D. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene. 2008 Jul 10;27(30):4210-20. doi: 10.1038/onc.2008.54. Epub 2008 Mar 17. PubMed PMID: 18345031.
3. Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF. Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6. J Cell Biochem. 2017 May 17. doi: 10.1002/jcb.26135. [Epub ahead of print] PubMed PMID: 28513872.
4. Guo Y, Liu S, Wang P, Zhang H, Wang F, Bing L, Gao J, Yang J, Hao A. Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression. J Neurosci Res. 2014 Jun;92(6):751-60. PubMed PMID: 24829950.

Products are for research use only. Not for human use.