Aurora A Inhibitor I

Catalog No. size PriceQuantity
M6681-2 2mg solid $145
M6681-10 10mg solid $603


Aurora A Inhibitor I is a selective inhibitor of Aurora kinase A.

Product information

CAS Number: 1158838-45-9

Molecular Weight: 588.07

Formula: C31H31ClFN7O2


TC-S 7010


TC S 7010

Aurora A Inhibitor I

Chemical Name: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide

Smiles: CCN1CCN(CC1)C(=O)CC1C=CC(=CC=1)NC1=NC(NC2C=CC(=CC=2)C(=O)NC2=CC=CC=C2Cl)=C(F)C=N1


InChi: InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Aurora A Inhibitor I is exceptionally selective Aurora A inhibitors. Aurora A Inhibitor I is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B.


  1. Lee DH, Kim CG, Lim Y, Shin SY. Aurora kinase A inhibitor Aurora A Inhibitor Idemonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells. Oncol Lett. 2017 Dec;14(6):6571-6577. doi: 10.3892/ol.2017.7023. Epub 2017 Sep 22. PubMed PMID: 29163689; PubMed Central PMCID: PMC5686436.

Products are for research use only. Not for human use.

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