Ethofibrate

Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.

Product information

CAS Number: 31637-97-5

Molecular Weight: 363.79

Formula: C18H18ClNO5

Chemical Name: Ethofibrate

Smiles: CC(C)(OC1C=CC(Cl)=CC=1)C(=O)OCCOC(=O)C1=CN=CC=C1

InChiKey: XXRVYAFBUDSLJX-UHFFFAOYSA-N

InChi: InChI=1S/C18H18ClNO5/c1-18(2,25-15-7-5-14(19)6-8-15)17(22)24-11-10-23-16(21)13-4-3-9-20-12-13/h3-9,12H,10-11H2,1-2H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 73 mg/mL (200.67 mM) Ethanol 73 mg/mL (200.67 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Etofibrate treatment heightens the cytosolic glycerol-3-phosphate dehydrogenase activity and the total carnitine concentration in the liver of rats, whereas it reduces triacylglycerol and cholesterol concentrations. Etofibrate decreases plasma levels of cholesterol, triacylglycerols, free fatty acids (FFA) and glycerol, as well as the total and unesterified cholesterol concentrations, in liver microsomes of rats. Etofibrate increases the activity of liver cytosolic glycerol-3-P dehydrogenase in the rats, whereas it decreases the activity of both microsomal HMG-CoA reductase and cholesterol 7 alpha-hydroxylase and does not affect acyl-CoA: cholesterol acyltransferase (ACAT). Etofibrate decreases the availability of lipolytic products in the liver by acting on their release from adipose tissue and on their intrinsic hepatic metabolism. Etofibrate stimulates the rate of fatty acid re-esterification when incubations are done under basal conditions in epididymal fat pad pieces from fed rats.

In Vivo:

Etofibrate (1.2 mM/g) decreases plasma FFA levels in male Sprague-Dawley rats, Etofibrate enhances or decreases plasma glycerol levels depending on both the dose and the time after treatment. Etofibrate (200 mg/kg) causes a significant inhibition of the proliferation of the smooth muscle cells in the intimal proliferate which consequently results in a less pronounced plaque in a rabbit model of atherosclerosis.

References:

1. Herrera E, et al. Biochim Biophys Acta, 1988, 963(1), 42-52.
2. Bocos C, et al. Biochim Biophys Acta, 1993, 1168(3), 340-347.
3. Bocos C, et al. Environ Toxicol Pharmacol, 1996, 2(4), 351-357.
4. Betz E, et al. Vasa, 1990, 19(2), 157-160.

Products are for research use only. Not for human use.