LDN-212320


Catalog No. size PriceQuantity
M6695-2 2mg solid $115
M6695-10 10mg solid $488

Description

LDN-0212320 Maleate is a novel activator of glutamate transporter EAAT2 translation.

Product information

CAS Number: 894002-50-7

Molecular Weight: 409.46

Formula: C21H19N3O4S

Synonym:

LDN-0212320

HY-12741

Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine maleate

Smiles: CC1=CC=CC=C1CSC1=CC=C(N=N1)C1=CC=CC=N1.OC(=O)/C=C\C(O)=O

InChiKey: QIGJQEQXFAVIPF-BTJKTKAUSA-N

InChi: InChI=1S/C17H15N3S.C4H4O4/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15;5-3(6)1-2-4(7)8/h2-11H,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vivo:

LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior. LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC. LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC.

References:

  1. Arendowski A, Ruman T. Laser Desorption/Ionisation Mass Spectrometry Imaging of European Yew (Taxus baccata) on Gold Nanoparticle-enhanced Target. Phytochem Anal. 2017 May 19. doi: 10.1002/pca.2693. [Epub ahead of print] PubMed PMID: 28523824.
  2. Hirahara M, Fujiwara N, Seo K. Novel trigeminal slice preparation method for studying mechanisms of nociception transmission. J Neurosci Methods. 2017 May 15. pii: S0165-0270(17)30146-2. doi: 10.1016/j.jneumeth.2017.05.019. [Epub ahead of print] PubMed PMID: 28522210.
  3. Kim SY, Park S, Yoo S, Rho JK, Jun ES, Chang S, Kim KK, Kim SC, Kim I. Downregulation of X-linked inhibitor of apoptosis protein by '7-Benzylidenenaltrexone maleate' sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. Oncotarget. 2017 May 12. doi: 10.18632/oncotarget.17841. [Epub ahead of print] PubMed PMID: 28521307.
  4. Mohammadi Z, Jafarzadeh H, Shalavi S, Kinoshita JI. Unusual Root Canal Irrigation Solutions. J Contemp Dent Pract. 2017 May 1;18(5):415-420. PubMed PMID: 28512283.

Products are for research use only. Not for human use.

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