LDN-212320


Catalog No. size PriceQuantity
M6695-2 2mg solid $115
M6695-10 10mg solid $488

Description

Cas:894002-50-7

Product Information

LDN-212320 Maleate is a novel activator of glutamate transporter EAAT2 translation.

 

Chemical Formula: C21H19N3O4S

 

Exact Mass: 409.1096

 

Molecular Weight: 409.46

 

Elemental Analysis: C, 61.60; H, 4.68; N, 10.26; O, 15.63; S, 7.83

 

Synonym: 

 

894002-50-7

LDN-212320

LDN 212320

3-[(2-methylphenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine

3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine

LDN-0212320

F2005-0208

C17H15N3S

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine

CHEMBL1834164

SCHEMBL14685055

AOB2666

SYN5193

LDN/OSU-0212320

ZINC4358191

3771AH

AKOS024458486

CS-3927

MCULE-7001577076

AS-16553

HY-12741

SR-01000909725

3-(2-methylbenzylthio)-6-(pyridin-2-yl)pyridazine

SR-01000909725-1

LDN/OSU-0212320;LDN-0212320;OSU-0212320

 

Chemical Name:

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine maleate

 

InChi Key:

QIGJQEQXFAVIPF-BTJKTKAUSA-N

 

InChi Code: InChI=1S/C17H15N3S.C4H4O4/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15;5-3(6)1-2-4(7)8/h2-11H,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

 

Smiles Code:

CC1=CC=CC=C1CSC2=NN=C(C3=NC=CC=C3)C=C2.O=C(O)/C=C\C(O)=O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vivo

LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior.

LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC.

LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC.

 

 

References

 

  1. Arendowski A, Ruman T. Laser Desorption/Ionisation Mass Spectrometry Imaging of European Yew (Taxus baccata) on Gold Nanoparticle-enhanced Target. Phytochem Anal. 2017 May 19. doi: 10.1002/pca.2693. [Epub ahead of print] PubMed PMID: 28523824.

 

  1. Hirahara M, Fujiwara N, Seo K. Novel trigeminal slice preparation method for studying mechanisms of nociception transmission. J Neurosci Methods. 2017 May 15. pii: S0165-0270(17)30146-2. doi: 10.1016/j.jneumeth.2017.05.019. [Epub ahead of print] PubMed PMID: 28522210.

 

  1. Kim SY, Park S, Yoo S, Rho JK, Jun ES, Chang S, Kim KK, Kim SC, Kim I. Downregulation of X-linked inhibitor of apoptosis protein by '7-Benzylidenenaltrexone maleate' sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. Oncotarget. 2017 May 12. doi: 10.18632/oncotarget.17841. [Epub ahead of print] PubMed PMID: 28521307.

 

  1. Mohammadi Z, Jafarzadeh H, Shalavi S, Kinoshita JI. Unusual Root Canal Irrigation Solutions. J Contemp Dent Pract. 2017 May 1;18(5):415-420. PubMed PMID: 28512283.

 

  1. Mizoue S, Nitta K, Shirakashi M, Nitta A, Yamabayashi S, Kimura T, Ueda T, Takeda R, Matsumoto S, Yoshikawa K. Multicenter, Randomized, Investigator-Masked Study Comparing Brimonidine Tartrate 0.1% and Timolol Maleate 0.5% as Adjunctive Therapies to Prostaglandin Analogues in Normal-Tension Glaucoma. Adv Ther. 2017 May 15. doi: 10.1007/s12325-017-0552-5. [Epub ahead of print] PubMed PMID: 28508306.

 

Products are for research use only. Not for human use.

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