WAY262611 HCl is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3.
CAS Number: 1123231-07-1
Molecular Weight: 391.34
WAY 262611 dihydrochloride
WAY-262611 dihydrochloride WAY 262611 dihydrochloride
Chemical Name: (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine Dihydrochloride
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1.
- Polakis P. Wnt signaling and cancer. Genes Dev. 2000 Aug 1;14(15):1837-51. Review. PubMed PMID: 10921899.
Products are for research use only. Not for human use.
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