ML-098


Catalog No. size PriceQuantity
M6710-2 2mg solid $88
M6710-10 10mg solid $356

Description

Cas:878978-76-8

Product Information

ML-098, also known as CID-7345532, is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM). ML098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II.

 

Chemical Formula: C19H19NO3

 

Exact Mass: 309.1365

 

Molecular Weight: 309.365

 

Elemental Analysis: C, 73.77; H, 6.19; N, 4.53; O, 15.51

 

Synonym: 

 

ML-098

ML 098

ML098

CID-7345532

CID 7345532

CID7345532

 

Chemical Name:

1-(2-(2,5-dimethylphenoxy)ethyl)-1H-indole-3-carboxylic acid

 

InChi Key:

LILIWWFBJKBUCO-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C19H19NO3/c1-13-7-8-14(2)18(11-13)23-10-9-20-12-16(19(21)22)15-5-3-4-6-17(15)20/h3-8,11-12H,9-10H2,1-2H3,(H,21,22)

 

Smiles Code:

O=C(C1=CN(CCOC2=CC(C)=CC=C2C)C3=C1C=CC=C3)O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro

Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).

 

 

References

 

  1. Surviladze Z, Ursu O, Miscioscia F, Curpan R, Halip L, Bologa C, Oprea T, Waller A, Strouse J, Salas V, Wu Y, Edwards B, Wandinger-Ness A, Sklar L. Three small molecule pan activator families of Ras-related GTPases. 2009 May 18 [updated 2010 Sep 2]. Probe Reports from the NIH Molecular Libraries Program [Internet].

 

Products are for research use only. Not for human use.

 

 

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