KN-93 Phosphate

Catalog No. size PriceQuantity
M6714-2 2mg solid $103
M6714-10 10mg solid $391


Cas:1188890-41-6 (phosphate)

Product Information

KN-93 Phosphate is a CaMKII inhibitor. KN-93 suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. KN-93 ameliorates levodopa-induced dyskinesia in a rat model of Parkinson's disease. KN-93 protects rat cerebral cortical neurons from N-methyl-D-aspartic acid-induced injury.


Chemical Formula: C26H32ClN2O8PS


Molecular Weight: 599.0318


Elemental Analysis: C, 52.13; H, 5.38; Cl, 5.92; N, 4.68; O, 21.37; P, 5.17; S, 5.35





KN 93


KN-93 phosphate


Chemical Name:

(E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate


InChi Key:



InChi Code:



Smiles Code:




Technical Data:


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001





  1. Ebrahimi F, Sadr SS, Roghani M, Khamse S, Mohammadian Haftcheshmeh S, Navid Hamidi M, Mohseni-Moghaddam P, Zamani E. Assessment of the protective effect of KN-93 drug in systemic epilepsy disorders induced by pilocarpine in male rat. J Cell Biochem. 2019 Sep;120(9):15906-15914. doi: 10.1002/jcb.28864. Epub 2019 May 9. PMID: 31074121.


  1. Wong MH, Samal AB, Lee M, Vlach J, Novikov N, Niedziela-Majka A, Feng JY, Koltun DO, Brendza KM, Kwon HJ, Schultz BE, Sakowicz R, Saad JS, Papalia GA. The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM. J Mol Biol. 2019 Mar 29;431(7):1440-1459. doi: 10.1016/j.jmb.2019.02.001. Epub 2019 Feb 10. PMID: 30753871.


  1. Hegyi B, Chen-Izu Y, Jian Z, Shimkunas R, Izu LT, Banyasz T. KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol. 2015 Dec;89(Pt B):173-6. doi: 10.1016/j.yjmcc.2015.10.012. Epub 2015 Oct 14. PMID: 26463508; PMCID: PMC4689637.


  1. Takeuchi M, Yamamoto T. Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Exp Cell Res. 2015 Jul 1;335(1):62-7. doi: 10.1016/j.yexcr.2015.05.019. Epub 2015 May 27. PMID: 26024774.


  1. Koga T, Mizui M, Yoshida N, Otomo K, Lieberman LA, Crispín JC, Tsokos GC. KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice. Autoimmunity. 2014 Nov;47(7):445-50. doi: 10.3109/08916934.2014.915954. Epub 2014 May 15. PMID: 24829059; PMCID: PMC4341833.


Products are for research use only. Not for human use.


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