Description
Brasofensine, CAS No. 171655-91-7, is a monoamine reuptake blocker is a phenyltropane that had been under development for the treatment of Parkinson's and Alzheimer's disease. In animal models of Parkinson's disease, brasofensine was effective in stimulating LMA and reversing akinesia. The (Z)-isomer has been consigned the name BMS-205912.
Product information
CAS Number: 171655-91-7
Molecular Weight: 327.25
Formula: C16H20Cl2N2O
Synonym:
(E)-1R,2R,3S-3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carbaldehyde O-methyloxime
brasofensine
BMS 204756
NS2214
Chemical Name: (E)-1R, 2R, 3S-3-(3, 4-dichlorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carbaldehyde O-methyloxime
Smiles: CO/N=C/[C@H]1[C@H]2CC[C@@H](C[C@@H]1C1C=CC(Cl)=C(Cl)C=1)N2C
InChiKey: NRLIFEGHTNUYFL-QJDHNRDASA-N
InChi: InChI=1S/C16H20Cl2N2O/c1-20-11-4-6-16(20)13(9-19-21-2)12(8-11)10-3-5-14(17)15(18)7-10/h3,5,7,9,11-13,16H,4,6,8H2,1-2H3/b19-9+/t11-,12+,13+,16+/m0/s1
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO, not in water
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Frackiewicz EJ, Jhee SS, Shiovitz TM, Webster J, Topham C, Dockens RC, Whigan D, Salazar DE, Cutler NR. Brasofensine treatment for Parkinson's disease in combination with levodopa/carbidopa. Ann Pharmacother. 2002 Feb;36(2):225-30. PubMed PMID: 11847938.
- Pearce RK, Smith LA, Jackson MJ, Banerji T, Scheel-Krüger J, Jenner P. The monoamine reuptake blocker brasofensine reverses akinesia without dyskinesia in MPTP-treated and levodopa-primed common marmosets. Mov Disord. 2002 Sep;17(5):877-86. PubMed PMID: 12360536.
- Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004 Jul;5(7):720-6. Review. PubMed PMID: 15298067.
Products are for research use only. Not for human use.
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