AMG-9810


Catalog No. size PriceQuantity
M6777-2 2mg solid $104
M6777-10 10mg solid $411

Description

Cas:545395-94-6

Product Information

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1). Additionally, it has been shown to compete with other modes of TRPV1 activation, including proton, heat, and the endogenous ligands: anandamide, N-arachidonyl dopamine and oleoyldopamine.

 

Synonyms:

 

(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide

3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide

AMG 9810

AMG-9810

AMG9810

 

Chemical Name:

3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide

 

InChi Key: 

GZTFUVZVLYUPRG-IZZDOVSWSA-N

 

InChi Code:

InChI=1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+

 

Smiles Code:

CC(C)(C)c1ccc(cc1)/C=C/C(=O)Nc2ccc3c(c2)OCCO3

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

References

 

  1. Xu XX, Cao Y, Ding TT, Fu KY, Li Y, Xie QF. Role of TRPV1 and ASIC3 channels in experimental occlusal interference-induced hyperalgesia in rat masseter muscle. Eur J Pain. 2016 Apr;20(4):552-63. doi: 10.1002/ejp.758. Epub 2015 Jul 22. PubMed PMID: 26201614.

 

  1. Alawi KM, Aubdool AA, Liang L, Wilde E, Vepa A, Psefteli MP, Brain SD, Keeble JE. The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature. FASEB J. 2015 Oct;29(10):4285-98. doi: 10.1096/fj.15-272526. Epub 2015 Jul 1. PubMed PMID: 26136480; PubMed Central PMCID: PMC4650996.

 

  1. Qiao H, Gao Y, Zhang C, Zhou H. Increased expression of TRPV1 in the trigeminal ganglion is involved in orofacial pain during experimental tooth movement in rats. Eur J Oral Sci. 2015 Feb;123(1):17-23. doi: 10.1111/eos.12158. Epub 2014 Nov 19. PubMed PMID: 25407056.

 

  1. Clifton HL, Inceoglu B, Ma L, Zheng J, Schaefer S. TRPV1 channels are involved in niacin-induced cutaneous vasodilation in mice. J Cardiovasc Pharmacol. 2015 Feb;65(2):184-91. doi: 10.1097/FJC.0000000000000181. PubMed PMID: 25387247.

 

  1. Yu X, Hu Y, Yu S. Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G471-8. doi: 10.1152/ajpgi.00156.2014. Epub 2014 Jul 3. PubMed PMID: 24994852; PubMed Central PMCID: PMC4137112.

 

  1. Amiresmaili S, Shamsizadeh A, Allahtavakoli M, Pourshanazari AA, Roohbakhsh A. The effect of intra-ventral hippocampus administration of TRPV1 agonist and antagonist on spatial learning and memory in male rats. Pharmacol Rep. 2014 Feb;66(1):10-4. doi: 10.1016/j.pharep.2013.06.002. Epub 2014 Jan 30. PubMed PMID: 24905300.

 

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