CGP60474 is a potent dual cdk1/cdk2 inhibitor (IC50 values are 20 and 50 nM, respectively). Also displays low micromolar activity at PKCα. Displays reversible G1/S cell cycle arrest in U2-OS cells.
Chemical Formula: C18H18ClN5O
Exact Mass: 355.11999
Molecular Weight: 355.83
Elemental Analysis: C, 60.76; H, 5.10; Cl, 9.96; N, 19.68; O, 4.50
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP.
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Products are for research use only. Not for human use.