CGP60474


Catalog No. size PriceQuantity
M6799-2 2mg solid $103
M6799-10 10mg solid $401

Description

Cas:164658-13-3

Product Information

CGP60474 is a potent dual cdk1/cdk2 inhibitor (IC50 values are 20 and 50 nM, respectively). Also displays low micromolar activity at PKCα. Displays reversible G1/S cell cycle arrest in U2-OS cells.

 

Chemical Formula: C18H18ClN5O

 

Exact Mass: 355.11999

 

Molecular Weight: 355.83

 

Elemental Analysis: C, 60.76; H, 5.10; Cl, 9.96; N, 19.68; O, 4.50

 

Synonym:

 

CGP60474

CGP-60474

CGP 60474.

 

Chemical Name:

3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol

 

InChi Key:

IYNDTACKOAXKBJ-UHFFFAOYSA-N

 

InChi Code:

InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24)

 

Smiles Code:

OCCCNC1=NC=CC(C2=NC(NC3=CC=CC(Cl)=C3)=NC=C2)=C1

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP.

 

 

References

 

  1. Kuo GH, Deangelis A, Emanuel S, Wang A, Zhang Y, Connolly PJ, Chen X, Gruninger RH, Rugg C, Fuentes-Pesquera A, Middleton SA, Jolliffe L, Murray WV. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem. 2005 Jul 14;48(14):4535-46. PubMed PMID: 15999992.

 

  1. Stanetty P, Hattinger G, Schnürch M, Mihovilovic MD. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem. 2005 Jun 24;70(13):5215-20. PubMed PMID: 15960526.

 

Products are for research use only. Not for human use.

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