Catalog No. size PriceQuantity
M6801-2 2mg solid $98
M6801-10 10mg solid $396


Sphingosine is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase. D-sphingosine, a lipid possessing the same hydrophobic base as ceramide but without a carbohydrate residue, efficiently blocked this glycolipid antigen presentation both in vitro and in spinal cords of EAE mice, and significantly decreased IL-17 and ameliorated the pathological symptoms.

Product information

CAS Number: 123-78-4

Molecular Weight: 299.49

Formula: C18H37NO2



Sphingosine (d18:1)

erythro-Sphingosine C-18

Chemical Name: 2S-amino-4E-octadecene-1,3R-diol



InChi: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells.


  1. Resuello DL, Lirio SB, Porto AE, Macabeo APG, Huang HY, Corpuz MJT, Villaflores OB. β-secretase 1 inhibitory activity and AMP-activated protein kinase activation of Callyspongia samarensis extracts. Nat Prod Res. 2020 Feb;34(4):525-529. doi: 10.1080/14786419.2018.1488699. Epub 2018 Nov 14. PMID: 30427208.
  2. Cleary JM, Lipsky ZW, Kim M, Marques CNH, German GK. Heterogeneous ceramide distributions alter spatially resolved growth of Staphylococcus aureus on human stratum corneum. J R Soc Interface. 2018 Apr;15(141):20170848. doi: 10.1098/rsif.2017.0848. PMID: 29669890; PMCID: PMC5938579.
  3. Pavlova NV, Li SC, Li YT. Degradation of glycosphingolipids in oyster: ceramide glycanase and ceramidase in the hepatopancreas of oyster, Crassostrea virginica. Glycoconj J. 2018 Feb;35(1):77-86. doi: 10.1007/s10719-017-9802-7. Epub 2017 Oct 16. PMID: 29039121.

Products are for research use only. Not for human use.

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