Daphnetin


Catalog No. size PriceQuantity
M6806-2 2mg solid $120
M6806-10 10mg solid $494

Description

Cas:486-35-1

Product Information

Daphnetin is a coumarin derivative that has been isolated from plants of the genus Daphne and has diverse biological activities, including kinase inhibitory, anti-proliferative, and antioxidative properties.

 

Chemical Formula: C9H6O4

 

Exact Mass: 178.0266

 

Molecular Weight: 178.143

 

Elemental Analysis: C, 60.68; H, 3.40; O, 35.92

 

Synonym:

 

Daphnetin

7,8-Dihydroxycoumarin

NSC 633563

 

Chemical Name:

7,8-dihydroxy-2H-1-benzopyran-2-one

 

InChi Key:

ATEFPOUAMCWAQS-UHFFFAOYSA-N

 

InChi Code: 

InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

 

Smiles Code:

O=C1C=CC2=CC=C(O)C(O)=C2O1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

 

 

References

 

  1. Yang, E.B., Zhao, Y.N., Zhang, K., et al. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem. Biophys. Res. Commun. 260(3), 682-685 (1999).

 

  1. Jiménez-Orozco, F.A., Rosales, A.A., Vega-López, A., et al. Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. Eur. J. Pharmacol. 668(1-2), 35-41 (2011).

 

  1. Lv, H., Liu, Q., Zhou, J., et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic. Biol. Med. 106, 38-52 (2017).

 

Products are for research use only. Not for human use.

 

 

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