Phorbol 12,13-dibutyrate

Cas：37558-16-0

Product Information：

Phorbol 12,13-dibutyrate, also known as PDBu, is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.

Chemical Formula: C28H40O8

Exact Mass: 504.2723

Molecular Weight: 504.62

Elemental Analysis: C, 66.65; H, 7.99; O, 25.36

Synonym:

PDBu

Phorbol 12,13-dibutyrate

Phorbol dibutyrat

Chemical Name:

Phorbol 12,13-dibutanoate

InChi Key:

BQJRUJTZSGYBEZ-YVQNUNKESA-N

InChi Code:

InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1

Smiles Code:

OCC1=C[C@@]2([H])[C@H](C3(C)C)[C@@]3(OC(CCC)=O)[C@H](OC(CCC)=O)[C@@H](C)[C@@]2([C@@]([H])([C@@]4(C1)O)C=C(C4=O)C)O

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

In Vitro：

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (1 MM) activates PKC and inhibited Na/K-ATPase transport activity in OK cells.

References：

1. Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, Konishi H, Kikkawa U, Kashiwagi K, Saito N. Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol Ther. 2002 Feb-Mar;93(2-3):271-81. Review. PubMed PMID: 12191619.

2. Thatcher WW, Guzeloglu A, Mattos R, Binelli M, Hansen TR, Pru JK. Uterine-conceptus interactions and reproductive failure in cattle. Theriogenology. 2001 Dec 1;56(9):1435-50. Review. PubMed PMID: 11768809.

3. Dell CP. Antiproliferative naphthopyrans: biological activity, mechanistic studies and therapeutic potential. Curr Med Chem. 1998 Jun;5(3):179-94. Review. PubMed PMID: 9562601.

4. Van der Zee EA, Luiten PG, Disterhoft JF. Learning-induced alterations in hippocampal PKC-immunoreactivity: a review and hypothesis of its functional significance. Prog Neuropsychopharmacol Biol Psychiatry. 1997 Apr;21(3):531-72. Review. PubMed PMID: 9153071.

5. Quest AF, Ghosh S, Xie WQ, Bell RM. DAG second messengers: molecular switches and growth control. Adv Exp Med Biol. 1997;400A:297-303. Review. PubMed PMID: 9547571.

Products are for research use only. Not for human use.