p32-IN-M36 is an inhibitor of p32 mitochondrial protein, which binds directly to p32 and blocks p32 association with LyP-1.
CAS Number: 802555-85-7
Molecular Weight: 448.52
p32 inhibitor M36
Chemical Name: 1,1'-(Propane-1,3-diyl)bis(3-(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)urea)
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
p32 Inhibitor M36 inhibits SF188 glioma cells proliferation (IC50 of 77.9 μM in complete media) and is much more potent under low glucose conditions with an IC50 of 7.3 μM. p32 Inhibitor M36 is selective for p32 overexpressing cells. p32 Inhibitor M36 is also a potent inhibitor of patient-derived neurospheres with an IC50 of 2.8 μM.
- Yenugonda V, Nomura N, Kouznetsova V, Tsigelny I, Fogal V, Nurmemmedov E, Kesari S, Babic I. A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma. J Transl Med. 2017 Oct 18;15(1):210. doi: 10.1186/s12967-017-1312-7. PubMed PMID: 29047383; PubMed Central PMCID: PMC5648515.
Products are for research use only. Not for human use.
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