Bisindolylmaleimide X hydrochloride


Catalog No. size PriceQuantity
M6816-2 2mg solid $92
M6816-10 10mg solid $360

Description

Cas:145317-11-9

Product Information

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM.

 

Synonyms:

 

BIM-X hydrochloride

Ro31-8425 hydrochloride

 

IC50 & TargetPKC   CDK2

200 nM (IC50)

 

Molecular Weight460.96

 

Chemical Formula:C₂₆H₂₅ClN₄O₂

 

Smiles Code:

 

O=C(C(C1=C(CC(CN)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O.[H]Cl

 

Shipping

Room temperature in continental US; may vary elsewhere.

 

Storage Condition:  

 

4°C, protect from light

 

In Vitro:

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride; Ro31-8425 hydrochloride) derivatives acts as an useful tool to compare inhibitor potencies and selectivities for a target of interest.

 

 

References

 

  1. Brehmer D, et al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500.

 

Products are for research use only. Not for human use.

 

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