Procyanidin A1

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

Product information

CAS Number: 103883-03-0

Molecular Weight: 576.50

Formula: C30H24O12

Synonym:

Proanthocyanidin A1

Chemical Name: Procyanidin A1

Smiles: O[C@@H]1[C@@H]2C3=C(C=C(O)C=C3O)O[C@]1(OC1=CC(O)=C3C[C@H](O)[C@H](OC3=C12)C1=CC(O)=C(O)C=C1)C1=CC(O)=C(O)C=C1

InChiKey: NSEWTSAADLNHNH-TXZJYACMSA-N

InChi: InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2/t21-,26+,27+,29+,30-/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin.

References:

1. Tomochika K, et al. Effects of peanut-skin procyanidin A1 on degranulation of RBL-2H3 cells. Biosci Biotechnol Biochem. 2011;75(9):1644-8.
2. Takano F, et al. Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biol Pharm Bull. 2007 May;30(5):922-7.

Products are for research use only. Not for human use.