O-Desmethyl Midostaurin


Catalog No. size PriceQuantity
M6829-2 2mg solid $658
M6829-10 10mg solid $2,636

Description

Cas:740816-86-8

Product Information

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

 

Synonyms:

 

CGP62221

O-Desmethyl PKC412

 

IC50 & Target: IC50:active metabolite of Midostaurin

 

Molecular Weight: 556.61

 

Chemical Formula: C₃₄H₂₈N₄O₄

 

Smiles Code:

O=C(N([C@@H]1C[C@]([H])(N2C3=C4C=CC=C3)O[C@](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[C@@H]1O)C)C9=CC=CC=C9

 

Shipping:

Room temperature in continental US; may vary elsewhere.

 

Storage Condition:

Please store the product under the recommended conditions in the Certificate of Analysis.

 

 

References

 

  1. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.

 

Products are for research use only. Not for human use.

 

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