Description
Cas：740816-86-8
Product Information：
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
Synonyms:
CGP62221
O-Desmethyl PKC412
IC50 & Target: IC50:active metabolite of Midostaurin
Molecular Weight: 556.61
Chemical Formula: C₃₄H₂₈N₄O₄
Smiles Code:
O=C(N([C@@H]1C[C@]([H])(N2C3=C4C=CC=C3)O[C@](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[C@@H]1O)C)C9=CC=CC=C9
Shipping:
Room temperature in continental US; may vary elsewhere.
Storage Condition:
Please store the product under the recommended conditions in the Certificate of Analysis.
References：
- Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.
Products are for research use only. Not for human use.
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