Description
Cas:78957-85-4
Product Information:
A3 HCl is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.
Chemical Formula: C12H14Cl2N2O2S
Exact Mass: 320.0153
Molecular Weight: 321.216
Elemental Analysis: C, 44.87; H, 4.39; Cl, 22.07; N, 8.72; O, 9.96; S, 9.98
Chemical Name:
N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride
InChi Key:
VWAGIWCLJAQLAL-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H13ClN2O2S.ClH/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14;/h1-6,15H,7-8,14H2;1H
Smiles Code:
O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl
Technical Data:
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
In Vitro:
A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.
References:
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