A3 HCl

A3 HCl is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.

Product information

CAS Number: 78957-85-4

Molecular Weight: 321.22

Formula: C12H14Cl2N2O2S

Synonym:

A-3 hydrochloride

Chemical Name: N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride

Smiles: Cl.NCCNS(=O)(=O)C1=CC=CC2C1=CC=CC=2Cl

InChiKey: VWAGIWCLJAQLAL-UHFFFAOYSA-N

InChi: InChI=1S/C12H13ClN2O2S.ClH/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14;/h1-6,15H,7-8,14H2;1H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

A3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.

References:

1. Agunloye OM, Oboh G. Modulatory effect of caffeic acid on cholinesterases inhibitory properties of donepezil. J Complement Integr Med. 2017 Sep 22;15(1). pii: /j/jcim.2018.15.issue-1/jcim-2017-0016/jcim-2017-0016.xml. doi: 10.1515/jcim-2017-0016. PubMed PMID: 28941354.
2. Krishna KD, Pradip ST, Navin SR. Preparation and Optimization of Fast Dissolving Film of Naratr iptan Hydrochloride. Recent Pat Drug Deliv Formul. 2017;11(2):124-131. doi: 10.2174/1872211311666170213105001. PubMed PMID: 28201962.
3. Kohno K, Ohashi E, Sano O, Kusano H, Kunikata T, Arai N, Hanaya T, Kawata T, Nishimoto T, Fukuda S. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015 Jan 20;12(1):2. doi: 10.1186/s12950-014-0045-0. eCollection 2015. PubMed PMID: 25632271; PubMed Central PMCID: PMC4308844.

Products are for research use only. Not for human use.