A3 HCl


Catalog No. size PriceQuantity
M6834-2 2mg solid $108
M6834-10 10mg solid $396

Description

Cas:78957-85-4

Product Information

A3 HCl is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.

 

Chemical Formula: C12H14Cl2N2O2S

 

Exact Mass: 320.0153

 

Molecular Weight: 321.216

 

Elemental Analysis: C, 44.87; H, 4.39; Cl, 22.07; N, 8.72; O, 9.96; S, 9.98

 

Chemical Name: 

N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride

 

InChi Key: 

VWAGIWCLJAQLAL-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C12H13ClN2O2S.ClH/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14;/h1-6,15H,7-8,14H2;1H

 

Smiles Code:

O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.

 

 

References

 

  1. Gessi S, Bencivenni S, Battistello E, Vincenzi F, Colotta V, Catarzi D, Varano F, Merighi S, Borea PA, Varani K. Inhibition of A(2A) Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455. Front Pharmacol. 2017 Dec 1;8:888. doi: 10.3389/fphar.2017.00888. eCollection 2017. PubMed PMID: 29249971; PubMed Central PMCID: PMC5716981.

 

  1. Agunloye OM, Oboh G. Modulatory effect of caffeic acid on cholinesterases inhibitory properties of donepezil. J Complement Integr Med. 2017 Sep 22;15(1). pii: /j/jcim.2018.15.issue-1/jcim-2017-0016/jcim-2017-0016.xml. doi: 10.1515/jcim-2017-0016. PubMed PMID: 28941354.

 

  1. Krishna KD, Pradip ST, Navin SR. Preparation and Optimization of Fast Dissolving Film of Naratr iptan Hydrochloride. Recent Pat Drug Deliv Formul. 2017;11(2):124-131. doi: 10.2174/1872211311666170213105001. PubMed PMID: 28201962.

 

  1. Kohno K, Ohashi E, Sano O, Kusano H, Kunikata T, Arai N, Hanaya T, Kawata T, Nishimoto T, Fukuda S. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015 Jan 20;12(1):2. doi: 10.1186/s12950-014-0045-0. eCollection 2015. PubMed PMID: 25632271; PubMed Central PMCID: PMC4308844.

 

  1. Vignozzi L, Filippi S, Comeglio P, Cellai I, Morelli A, Rastrelli G, Maneschi E, Mannucci E, Maggi M. Metformin in vitro and in vivo increases adenosine signaling in rabbit corpora cavernosa. J Sex Med. 2014 Jul;11(7):1694-708. doi: 10.1111/jsm.12572. Epub 2014 May 20. PubMed PMID: 24844317.

 

Products are for research use only. Not for human use.

 

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