A3 HCl

Catalog No. size PriceQuantity
M6834-2 2mg solid $108
M6834-10 10mg solid $396


A3 HCl is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.

Product information

CAS Number: 78957-85-4

Molecular Weight: 321.22

Formula: C12H14Cl2N2O2S


A-3 hydrochloride

Chemical Name: N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride

Smiles: Cl.NCCNS(=O)(=O)C1=CC=CC2C1=CC=CC=2Cl


InChi: InChI=1S/C12H13ClN2O2S.ClH/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14;/h1-6,15H,7-8,14H2;1H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

A3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.


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Products are for research use only. Not for human use.

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