A3 HCl

Cas：78957-85-4

Product Information：

A3 HCl is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.

Chemical Formula: C12H14Cl2N2O2S

Exact Mass: 320.0153

Molecular Weight: 321.216

Elemental Analysis: C, 44.87; H, 4.39; Cl, 22.07; N, 8.72; O, 9.96; S, 9.98

Chemical Name: 

N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride

InChi Key: 

VWAGIWCLJAQLAL-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H13ClN2O2S.ClH/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14;/h1-6,15H,7-8,14H2;1H

Smiles Code:

O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

In Vitro：

A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.

References：

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3. Krishna KD, Pradip ST, Navin SR. Preparation and Optimization of Fast Dissolving Film of Naratr iptan Hydrochloride. Recent Pat Drug Deliv Formul. 2017;11(2):124-131. doi: 10.2174/1872211311666170213105001. PubMed PMID: 28201962.

4. Kohno K, Ohashi E, Sano O, Kusano H, Kunikata T, Arai N, Hanaya T, Kawata T, Nishimoto T, Fukuda S. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015 Jan 20;12(1):2. doi: 10.1186/s12950-014-0045-0. eCollection 2015. PubMed PMID: 25632271; PubMed Central PMCID: PMC4308844.

5. Vignozzi L, Filippi S, Comeglio P, Cellai I, Morelli A, Rastrelli G, Maneschi E, Mannucci E, Maggi M. Metformin in vitro and in vivo increases adenosine signaling in rabbit corpora cavernosa. J Sex Med. 2014 Jul;11(7):1694-708. doi: 10.1111/jsm.12572. Epub 2014 May 20. PubMed PMID: 24844317.

Products are for research use only. Not for human use.