A3 HCl

Catalog No. size PriceQuantity
M6834-2 2mg solid $108
M6834-10 10mg solid $396



Product Information

A3 HCl is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.


Chemical Formula: C12H14Cl2N2O2S


Exact Mass: 320.0153


Molecular Weight: 321.216


Elemental Analysis: C, 44.87; H, 4.39; Cl, 22.07; N, 8.72; O, 9.96; S, 9.98


Chemical Name: 

N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride


InChi Key: 



InChi Code: InChI=1S/C12H13ClN2O2S.ClH/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14;/h1-6,15H,7-8,14H2;1H


Smiles Code:




Technical Data:


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


In Vitro:

A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.





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Products are for research use only. Not for human use.


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