Bisindolylmaleimide IV


Catalog No. size PriceQuantity
M6835-2 2mg solid $314
M6835-10 10mg solid $1,236

Description

Cas:119139-23-0

Product Information

Bisindolylmaleimide IV is an inhibitor of pyruvate phosphate dikinase (PPDK).

 

Chemical Formula: C20H13N3O2

 

Exact Mass: 327.1008

 

Molecular Weight: 327.34

 

Elemental Analysis: C, 73.38; H, 4.00; N, 12.84; O, 9.78

 

Chemical Name: 

3,4-Bis(1H-indol-3-yl)pyrrole-2,5-dione

 

InChi Key: 

DQYBRTASHMYDJG-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

 

Smiles Code:

O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO.

 

 

References

 

  1. Minges A, Groth G. Small-molecule inhibition of pyruvate phosphate dikinase targeting the nucleotide binding site. PLoS One. 2017 Jul 10;12(7):e0181139. doi: 10.1371/journal.pone.0181139. eCollection 2017. PubMed PMID: 28700696; PubMed Central PMCID: PMC5507339.

 

Products are for research use only. Not for human use.

 

 

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