Description
Cas：99570-78-2
Product Information：
K252b is a staurosporine analog and PKC inhibitor that suppresses DNA synthesis. It also inhibits microbial ectoprotein kinases and inhibits IgE cross-linking-dependent degranulation in basophils.
Chemical Formula: C26H19N3O5
Exact Mass: 453.1325
Molecular Weight: 453.45
Elemental Analysis: C, 68.87; H, 4.22; N, 9.27; O, 17.64
Chemical Name: 7-hydroxy-8-methyl-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxylic acid
InChi Key:
AMSOPBXQXSAAAC-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)
Smiles Code:
CC12C(C(O)=O)(O)CC(N3C4=CC=CC=C4C5=C6C(CNC6=O)=C7C8=CC=CC=C8N2C7=C53)O1
Technical Data：
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
References：
- Teshima R, Saito Y, Ikebuchi H, Rajiva De Silva N, Morita Y, Nakanishi M, Sawada J, Kitani S. Effect of an ectokinase inhibitor, K252b, on degranulation and Ca2+ signals of RBL-2H3 cells and human basophils. J Immunol. 1997 Jul 15;159(2):964-9. PubMed PMID: 9218617.
- Ross AH, McKinnon CA, Daou MC, Ratliff K, Wolf DE. Differential biological effects of K252 kinase inhibitors are related to membrane solubility but not to permeability. J Neurochem. 1995 Dec;65(6):2748-56. PubMed PMID: 7595574.
- Takeda M, Takahashi M, Hara N, Matsumoto S. Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammation. Brain Behav Immun. 2013 Feb;28:100-7. doi: 10.1016/j.bbi.2012.10.023. Epub 2012 Nov 3. PubMed PMID: 23131757.
- Bacot SM, Feldman GM, Yamada KM, Dhawan S. Pathogenic prion protein fragment (PrP106-126) promotes human immunodeficiency virus type-1 infection in peripheral blood monocyte-derived macrophages. Virology. 2015 Feb;476:372-6. doi: 10.1016/j.virol.2014.11.032. Epub 2015 Jan 9. PubMed PMID: 25589240; PubMed Central PMCID: PMC5282598.
- Makino K, Kawamura K, Sato W, Kawamura N, Fujimoto T, Terada Y. Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling. PLoS One. 2012;7(7):e41049. doi: 10.1371/journal.pone.0041049. Epub 2012 Jul 23. PubMed PMID: 22911740; PubMed Central PMCID: PMC3402458.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.