Hispidin


Catalog No. size PriceQuantity
M6840-2 2mg solid $144
M6840-10 10mg solid $570

Description

Cas:555-55-5

Product Information

Hispidin is a natural substance. It can also be synthetised. Hispidin 4-O-β-d-glucopyranoside can be found in Pteris ensiformis whereas hispidin derivatives, such as phellibaumins, can be found in the edible mushroom Inonotus xeranticus or Phellinus. Hispidin is a precursor of fungal luciferin, a compound responsible for light emission by luminous mushrooms.

 

Chemical Formula: C13H10O5

 

Exact Mass: 246.0528

 

Molecular Weight: 246.218

 

Elemental Analysis: C, 63.42; H, 4.09; O, 32.49

 

Chemical Name:

6-(3,4-Dihydroxystyryl)-4-hydroxy-2-pyrone

 

InChi Key: 

SGJNQVTUYXCBKH-HNQUOIGGSA-N

 

InChi Code: InChI=1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+

 

Smiles Code:

O=C1C=C(O)C=C(/C=C/C2=CC=C(O)C(O)=C2)O1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2932.20.3000

 

 

References

 

  1. Smolskaite L, Slapšyte G, Mierauskiene J, Dedonyte V, Venskutonis PR. Antioxidant and Genotoxic Properties of Hispidin Isolated from the Velvet-Top Mushroom, Phaeolus schweinitzii (Agaricomycetes). Int J Med Mushrooms. 2017;19(11):967-980. doi: 10.1615/IntJMedMushrooms.2017024522. PubMed PMID: 29345559.

 

  1. Song TY, Yang NC, Chen CL, Thi TLV. Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal-Induced Injuries in Rat Pheochromocytoma Cells. Oxid Med Cell Longev. 2017;2017:4824371. doi: 10.1155/2017/4824371. Epub 2017 Oct 17. PubMed PMID: 29181125; PubMed Central PMCID: PMC5664345.

 

  1. Tian LW, Feng Y, Tran TD, Shimizu Y, Pfeifer T, Vu HT, Quinn RJ. Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4007-4010. doi: 10.1016/j.bmcl.2017.07.062. Epub 2017 Jul 24. PubMed PMID: 28797798.

 

  1. Oba Y, Suzuki Y, Martins GNR, Carvalho RP, Pereira TA, Waldenmaier HE, Kanie S, Naito M, Oliveira AG, Dörr FA, Pinto E, Yampolsky IV, Stevani CV. Identification of hispidin as a bioluminescent active compound and its recycling biosynthesis in the luminous fungal fruiting body. Photochem Photobiol Sci. 2017 Sep 13;16(9):1435-1440. doi: 10.1039/c7pp00216e. PubMed PMID: 28766678.

 

  1. Wojtala A, Karkucinska-Wieckowska A, Sardao VA, Szczepanowska J, Kowalski P, Pronicki M, Duszynski J, Wieckowski MR. Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway. Mitochondrion. 2017 Nov;37:62-79. doi: 10.1016/j.mito.2017.07.002. Epub 2017 Jul 21. PubMed PMID: 28739512.

 

  1. Lee JS, Park JM, Lee S, Lee HJ, Yang HS, Yeo J, Lee KR, Choi BH, Hong EK. Hispidin rescues palmitate induced insulin resistance in C2C12 myotubes. Mol Med Rep. 2017 Oct;16(4):4229-4234. doi: 10.3892/mmr.2017.7042. Epub 2017 Jul 20. PubMed PMID: 28731188.

 

Products are for research use only. Not for human use.

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