Chroman 1

Catalog No. size PriceQuantity
M6843-2 2mg solid $148
M6843-10 10mg solid $603


Chroman 1 is a potent and selective ROCK II inhibitor (IC50: <1 nM for ROCK-II).

Product information

CAS Number: 1273579-40-0

Molecular Weight: 436.50

Formula: C24H28N4O4

Chemical Name: (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide

Smiles: COC1=CC2C[C@@H](COC=2C=C1)C(=O)NC1=CC=C(C=C1OCCN(C)C)C1=CNN=C1


InChi: InChI=1S/C24H28N4O4/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29)/t18-/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200


  1. Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75.

Products are for research use only. Not for human use.

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