Chroman 1


Catalog No. size PriceQuantity
M6843-2 2mg solid $148
M6843-10 10mg solid $603

Description

Cas:1273579-40-0

Product Information

Chroman 1 is a potent and selective ROCK II inhibitor (IC50: <1 nM for ROCK-II).

 

Chemical Formula: C24H28N4O4

 

Exact Mass: 436.2111

 

Molecular Weight: 436.512

 

Elemental Analysis: C, 66.04; H, 6.47; N, 12.84; O, 14.66

 

Chemical Name: (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide

 

Smiles Code:

O=C([C@@H]1COC2=C(C=C(OC)C=C2)C1)NC3=CC=C(C4=CNN=C4)C=C3OCCN(C)C

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75.

 

Products are for research use only. Not for human use.

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