Catalog No. size PriceQuantity
M6846-2 2mg solid $190
M6846-10 10mg solid $756



Product Information

HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity.


Molecular Weight:359.19


Chemical Formula: C₂₀H₁₈BN₃O₃


Smiles Code:





Room temperature in continental US; may vary elsewhere.


Storage Condition:


Powder       -20°C  3 years

4°C   2 years

In solvent   -80°C   6 months

-20°C   1 month


In Vitro:

HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration.

HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration.





  1. Dayal N, et al. Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. Eur J Med Chem. 2019 Oct 15;180:449-456.


Products are for research use only. Not for human use.



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