Description
Cas：2379279-96-4
Product Information：
HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity.
Molecular Weight：359.19
Chemical Formula: C₂₀H₁₈BN₃O₃
Smiles Code:
COC(C(B(O)O)=CC=C1)=C1C(C2=C3CCC2)=NC4=C3C(C=NN5)=C5C=C4
Shipping：
Room temperature in continental US; may vary elsewhere.
Storage Condition:
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
In Vitro：
HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration.
HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration.
References：
- Dayal N, et al. Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. Eur J Med Chem. 2019 Oct 15;180:449-456.
Products are for research use only. Not for human use.
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