BDP5290 HCl


Catalog No. size PriceQuantity
M6864-2 2mg solid $162
M6864-10 10mg solid $636

Description

Cas:1817698-21-7

Product Information

BDP5290 HCl is a MRCK inhibitor.

 

Chemical Formula: C17H19Cl2N7O

 

Exact Mass: 407.1028

 

Molecular Weight: 408.29

 

Elemental Analysis: C, 50.01; H, 4.69; Cl, 17.37; N, 24.01; O, 3.92

 

Synonym: 

 

BDP00005290

 

Chemical Name: 4-Chloro-1-(4-piperidyl)-N-[5-(2-pyridyl)-1H-pyrazol-4-yl]pyrazole-3-carboxamide Hydrochloride

 

InChi Key:

AROXEVUAHBCZOW-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C17H18ClN7O.ClH/c18-12-10-25(11-4-7-19-8-5-11)24-15(12)17(26)22-14-9-21-23-16(14)13-3-1-2-6-20-13;/h1-3,6,9-11,19H,4-5,7-8H2,(H,21,23)(H,22,26);1H

 

Smiles Code:

O=C(C1=NN(C2CCNCC2)C=C1Cl)NC3=C(C4=NC=CC=C4)NN=C3.[H]Cl

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

The Ki of BDP5290 for MRCKα is 10 nM, which is slightly more than the Ki of 4 nM for MRCKβ. 3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. At higher concentrations, BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels. BDP5290 reduces MDA-MB-231 invasion at all tested concentrations starting from 0.1 μM, with virtually complete inhibition at 10 μM. After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC50  >10 μM. Wound closure is inhibited by >60% at 1 μM BDP5290, a concentration that has no effect on cell viability.

 

 

References

 

  1. Unbekandt M, et al. A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Commun Signal. 2014 Oct 5;12:54.

 

Products are for research use only. Not for human use.

 

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