Description
Cas：2070014-88-7
Product Information：
SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect.
IC50 & Target：TGF-beta
Molecular Weight：365.94
Chemical Formula: C₂₀H₃₂ClN₃O
Smiles Code:
O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3.Cl[H]
Shipping：
Room temperature in continental US; may vary elsewhere.
Storage Condition:
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
In Vitro：
SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.
SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.
In Vivo：
SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration.
SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.
SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice.
SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%.
SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice.
References：
- Benzyl urea derivatives for activating tgf-beta signaling. US 20160039756 A1. 2016. Feb
- Liu Y, et al. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT. Int J Biol Sci. 2018 Oct 31;14(13):1923-1934.
Products are for research use only. Not for human use.
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