SRI-011381 hydrochloride

Catalog No. size PriceQuantity
M6877-2 2mg solid $132
M6877-10 10mg solid $535



Product Information

SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect.


IC50 & TargetTGF-beta


Molecular Weight365.94


Chemical Formula: C₂₀H₃₂ClN₃O


Smiles Code:





Room temperature in continental US; may vary elsewhere.


Storage Condition:


Powder     -20°C  3 years

4°C  2 years

In solvent -80°C  6 months

-20°C  1 month


In Vitro:

SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.

SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.


In Vivo

SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration.

SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.

SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice.

SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%.

SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice.





  1. Benzyl urea derivatives for activating tgf-beta signaling. US 20160039756 A1. 2016. Feb


  1. Liu Y, et al. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT. Int J Biol Sci. 2018 Oct 31;14(13):1923-1934.


Products are for research use only. Not for human use.


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