SRI-011381 hydrochloride


Catalog No. size PriceQuantity
M6877-2 2mg solid $132
M6877-10 10mg solid $535

Description

Cas:2070014-88-7

Product Information

SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect.

 

IC50 & TargetTGF-beta

 

Molecular Weight365.94

 

Chemical Formula: C₂₀H₃₂ClN₃O

 

Smiles Code:

 

O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3.Cl[H]

 

Shipping

Room temperature in continental US; may vary elsewhere.

 

Storage Condition:

 

Powder     -20°C  3 years

4°C  2 years

In solvent -80°C  6 months

-20°C  1 month

 

In Vitro:

SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.

SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.

 

In Vivo

SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration.

SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.

SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice.

SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%.

SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice.

 

 

References

 

  1. Benzyl urea derivatives for activating tgf-beta signaling. US 20160039756 A1. 2016. Feb

 

  1. Liu Y, et al. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT. Int J Biol Sci. 2018 Oct 31;14(13):1923-1934.

 

Products are for research use only. Not for human use.

 

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