SRI-011381 hydrochloride

Catalog No. size PriceQuantity
M6877-2 2mg solid $132
M6877-10 10mg solid $535


SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect[1].

Product information

CAS Number: 2070014-88-7

Molecular Weight: 365.94

Formula: C20H32ClN3O

Related CAS Number:

1629138-41-5 (free base)

Chemical Name: 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea hydrochloride



InChi: InChI=1S/C20H31N3O.ClH/c24-20(22-19-9-5-2-6-10-19)23(15-17-7-3-1-4-8-17)16-18-11-13-21-14-12-18;/h1,3-4,7-8,18-19,21H,2,5-6,9-16H2,(H,22,24);1H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 10 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages[1]. SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts[2].

In Vivo:

SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration[1]. SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin[1]. SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice[1]. SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%[1]. SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice[1].


  1. Benzyl urea derivatives for activating tgf-beta signaling. US 20160039756 A1. 2016. Feb
  2. Liu Y, et al. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT. Int J Biol Sci. 2018 Oct 31;14(13):1923-1934.

Products are for research use only. Not for human use.

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