EMT inhibitor-1


Catalog No. size PriceQuantity
M6882-2 2mg solid $196
M6882-10 10mg solid $796

Description

Cas:1638526-21-2

Product Information

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

 

IC50 & Target:Hippo, TGF-β, Wnt

Molecular Weight319.21  

 

Chemical Formula: C₁₂H₁₂Cl₂N₂O₂S

 

Smiles Code:

OCCCCOC1=NSN=C1C2=CC=C(Cl)C(Cl)=C2

 

Shipping:

Room temperature in continental US; may vary elsewhere.

 

Storage Condition:

Powder     -20°C   3 years

4°C   2 years

In solvent -80°C   6 months

-20°C   1 month

 

In Vitro:

EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.

 

In Vivo

EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).

 

 

References

 

  1. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.

 

Products are for research use only. Not for human use.

 

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