EMT inhibitor-1


Catalog No. size PriceQuantity
M6882-2 2mg solid $255
M6882-10 10mg solid $975

Description

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

Product information

CAS Number: 1638526-21-2

Molecular Weight: 319.21

Formula: C12H12Cl2N2O2S

Chemical Name: 4-(4-(3, 4-dichlorophenyl)-1, 2, 5-thiadiazol-3-yloxy)butan-1-ol

Smiles: OCCCCOC1=NSN=C1C1=CC(Cl)=C(Cl)C=C1

InChiKey: FWMUIOJZHOPPDX-UHFFFAOYSA-N

InChi: InChI=1S/C12H12Cl2N2O2S/c13-9-4-3-8(7-10(9)14)11-12(16-19-15-11)18-6-2-1-5-17/h3-4,7,17H,1-2,5-6H2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL (313.27 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.

In Vivo:

EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).

References:

  1. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.

Products are for research use only. Not for human use.

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