Hydrochlorothiazide


Catalog No. size PriceQuantity
M6883-2 2mg solid $97
M6883-10 10mg solid $401

Description

Cas:58-93-5

Product Information

Hydrochlorothiazide is a thiazide diuretic often used to treat high blood pressure and swelling due to fluid build up. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.

 

Chemical Formula: C7H8ClN3O4S2

 

Exact Mass: 296.96447

 

Molecular Weight: 297.74

 

Elemental Analysis: C, 28.24; H, 2.71; Cl, 11.91; N, 14.11; O, 21.49; S, 21.54

 

Related CAS #: 58-93-5  58-94-5  

 

Synonym:  

 

Hypothiazide

Dichlotride

Hydrosaluric

Esidrex

Dichlothiazide

Dihydrochlorothiazide

HCTZ

HydroDIURIL

Oretic

Sectrazide

 

Chemical Name: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide

 

InChi Key: 

JZUFKLXOESDKRF-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

 

Smiles Code:

C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

 

 

Technical Data:

 

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Dinç E, Ertekin ZC. Three-way analysis of the UPLC-PDA dataset for themulticomponent quantitation of hydrochlorothiazide and olmesartan medoxomil intablets by parallel factor analysis and three-way partial least squares. Talanta.2016 Feb 1;148:144-52. doi: 10.1016/j.talanta.2015.10.074. Epub 2015 Oct 26.PubMed PMID: 26653435.

 

  1. Machnicki G, Ong SH, Chen W, Wei ZJ, Kahler KH. Comparison ofamlodipine/valsartan/hydrochlorothiazide single pill combination and freecombination: adherence, persistence, healthcare utilization and costs. Curr MedRes Opin. 2015 Dec;31(12):2287-96. doi: 10.1185/03007995.2015.1098598. Epub 2015Nov 11. PubMed PMID: 26397178.

 

  1. Machini WB, David-Parra DN, Teixeira MF. Electrochemical investigation of thevoltammetric determination of hydrochlorothiazide using a nickel hydroxidemodified nickel electrode. Mater Sci Eng C Mater Biol Appl. 2015 Dec 1;57:344-8.doi: 10.1016/j.msec.2015.07.035. Epub 2015 Aug 11. PubMed PMID: 26354274.

 

  1. Arafa MF, El-Gizawy SA, Osman MA, El Maghraby GM. Sucralose as co-crystalco-former for hydrochlorothiazide: development of oral disintegrating tablets.Drug Dev Ind Pharm. 2015 Dec 7:1-9. [Epub ahead of print] PubMed PMID: 26555927.

 

Products are for research use only. Not for human use.

 

 

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