Pirfenidone D5


Catalog No. size PriceQuantity
M6889-2 2mg solid $250
M6889-10 10mg solid $1,008

Description

Cas:1020719-62-3

Product Information

Pirfenidone D5 (AMR69 D5) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities.

 

Synonyms:

 

AMR69 D5

 

IC50 & Target:

TGF-β2

CCL2 and CCL12

 

Molecular Weight:190.25

 

Chemical Formula:C₁₂H₆D₅NO

 

Smiles Code:

O=C1C=CC(C)=CN1C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]

 

Shipping:

Room temperature in continental US; may vary elsewhere.

 

Storage Condition:

Please store the product under the recommended conditions in the Certificate of Analysis.

 

 

References

 

  1. Burghardt I, et al. Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Biochem Biophys Res Commun. 2007 Mar 9;354(2):542-7.

 

  1. Nakazato H, et al. A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol. 2002 Jun 20;446(1-3):177-85.

 

  1. Inomata M, et al. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respir Res. 2014 Feb 8;15:16.

 

Products are for research use only. Not for human use.

 

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed