R-268712


Catalog No. size PriceQuantity
M6907-2 2mg solid $110
M6907-10 10mg solid $441

Description

Cas:879487-87-3

Product Information

R-268712 is a specific inhibitor of activin receptor-like kinase 5 (ALK5). It is also an orally active transforming growth factor-β type I receptor inhibitor.

 

Chemical Formula: C20H18FN5O

 

Exact Mass: 363.1495

 

Molecular Weight: 363.39

 

Elemental Analysis: C, 66.10; H, 4.99; F, 5.23; N, 19.27; O, 4.40

 

Chemical Name:

2-[4-[2-Fluoro-5-[3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl] phenyl] pyrazol-1-yl]ethanol

 

InChi Key:

JQGOCCALXFSRHZ-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C20H18FN5O/c1-13-3-2-4-19(24-13)20-17(11-22-25-20)14-5-6-18(21)16(9-14)15-10-23-26(12-15)7-8-27/h2-6,9-12,27H,7-8H2,1H3,(H,22,25)

 

Smiles Code:

CC1=CC=CC(C2=NNC=C2C3=CC=C(F)C(C4=CN(CCO)N=C4)=C3)=N1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Terashima H, Kato M, Ebisawa M, Kobayashi H, Suzuki K, Nezu Y, Sada T. R-268712, an orally active transforming growth factor-β type I receptor inhibitor, prevents glomerular sclerosis in a Thy1 nephritis model. Eur J Pharmacol. 2014 Jul 5;734:60-6. doi: 10.1016/j.ejphar.2014.03.045. Epub 2014 Apr 12. PubMed PMID: 24726873.

 

Products are for research use only. Not for human use.

 

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed