Catalog No. size PriceQuantity
M6909-2 2mg solid $98
M6909-10 10mg solid $406



Product Information

ML-347, also known as LDN193719, is a potent and selective bone morphogenetic protein receptor (BMP) inhibitor that inhibits ALK1 and ALK2 with IC50 values of 46 and 32 nM, respectively. ML347 shows >300-fold selectivity for ALK2.


Chemical Formula: C22H16N4O


Exact Mass: 352.1324


Molecular Weight: 352.397


Elemental Analysis: C, 74.98; H, 4.58; N, 15.90; O, 4.54




LDN 193719.


Chemical Name:



InChi Key: 



InChi Code: InChI=1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H,1H3


Smiles Code:




Technical Data:


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001





  1. Engers DW, Frist AY, Lindsley CW, Hong CH, Hopkins CR. Development of a potentand ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor. 2013 Apr12 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program[Internet]. Bethesda (MD): National Center for Biotechnology Information (US);2010-. Available from PMID: 25506972.


  1. Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. Synthesis andstructure-activity relationships of a novel and selective bone morphogeneticprotein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidinescaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selectiveMLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. doi:10.1016/j.bmcl.2013.03.113. Epub 2013 Apr 11. PubMed PMID: 23639540; PubMedCentral PMCID: PMC3677712.


Products are for research use only. Not for human use.

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