Description
ML-347, also known as LDN193719, is a potent and selective bone morphogenetic protein receptor (BMP) inhibitor that inhibits ALK1 and ALK2 with IC50 values of 46 and 32 nM, respectively. ML347 shows >300-fold selectivity for ALK2.
Product information
CAS Number: 1062368-49-3
Molecular Weight: 352.39
Formula: C22H16N4O
Synonym:
LDN 193719
LDN 193719.
Chemical Name: 5-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Smiles: COC1C=CC(=CC=1)C1=CN2N=CC(=C2N=C1)C1=CC=CC2=NC=CC=C21
InChiKey: FVRYPYDPKSZGNS-UHFFFAOYSA-N
InChi: InChI=1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H,1H3
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO, not in water
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Engers DW, Frist AY, Lindsley CW, Hong CH, Hopkins CR. Development of a potentand ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor. 2013 Apr12 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program[Internet]. Bethesda (MD): National Center for Biotechnology Information (US);2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK259191/PubMed PMID: 25506972.
- Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. Synthesis andstructure-activity relationships of a novel and selective bone morphogeneticprotein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidinescaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selectiveMLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. doi:10.1016/j.bmcl.2013.03.113. Epub 2013 Apr 11. PubMed PMID: 23639540; PubMedCentral PMCID: PMC3677712.
Products are for research use only. Not for human use.
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