A77-01


Catalog No. size PriceQuantity
M6910-2 2mg solid $98
M6910-10 10mg solid $411

Description

Cas:607737-87-1

Product Information

A 77-01 is an inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25nM.

 

Chemical Formula: C18H14N4

 

Exact Mass: 286.12185

Molecular Weight: 286.33

 

Elemental Analysis: C, 75.50; H, 4.93; N, 19.57

 

Chemical Name: 

4-(5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

 

InChi Key:

KJTYZDORHCDZPS-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22)

 

Smiles Code:

CC1=CC=CC(=N1)C2=C(C=NN2)C3=CC=NC4=CC=CC=C34

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

A-77-01 (0.01-10 µM; 25 hours; Mv1Lu cells) treatment effectively inhibits TGF-β-induced transcriptional activation in concentration-dependent fashion.

A-77-01 (1 µM; 24-72 hours; Mv1Lu cells) treatment efficiently prevents the growth-inhibitory effects of TGF-β.

A-77-01 (1 µM; 30 minutes; HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2.

 

 

References

  1. Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800.

 

Products are for research use only. Not for human use.

 

 

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