SM16


Catalog No. size PriceQuantity
M6912-2 2mg solid $106
M6912-10 10mg solid $452

Description

Cas:614749-78-9

Product Information

SM16 is a novel Type I TGF-β signaling inhibitor.

 

Chemical Formula: C25H26N4O3

 

Exact Mass: 430.2005

 

Molecular Weight: 430.508

 

Elemental Analysis: C, 69.75; H, 6.09; N, 13.01; O, 11.15

 

Chemical Name: 4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxamide

 

InChi Key:

JUHTXZGCTPDXRU-UHFFFAOYSA-N

 

InChi Code:

InChI=1S/C25H26N4O3/c1-15-3-2-4-17(27-15)21-20(16-5-6-18-19(13-16)32-14-31-18)28-23(29-21)25-10-7-24(8-11-25,9-12-25)22(26)30/h2-6,13H,7-12,14H2,1H3,(H2,26,30)(H,28,29)

 

Smiles Code:

O=C(C1(CC2)CCC2(C3=NC(C4=CC=C(OCO5)C5=C4)=C(C6=NC(C)=CC=C6)N3)CC1)N

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

SM 16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC50=64 nM) and TGFβ- or activin-induced Smad2 phosphorylation at concentrations between 100 and 620 nM. SM 16 is tested against >60 related and unrelated kinases and shows moderate off-target activity only against Raf (IC50=1 μM) and p38/SAPKa (IC50=0.8 μM). SM 16 exhibits no inhibitory activity against ALK family members ALK1 and ALK6.

In Vivo:

SM 16 penetrates tumor cells in vivo, suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single i.p. bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via s.c. miniosmotic pumps over 28 days.

 

 

References

 

  1. Hudalla H, Bruckner T, Pöschl J, Strowitzki T, Kuon RJ. Antenatal exposure to fenoterol is not associated with the development of retinopathy of prematurity in infants born before 32 weeks of gestation. Arch Gynecol Obstet. 2020 Mar;301(3):687-692. doi: 10.1007/s00404-020-05463-z. Epub 2020 Feb 28. PMID: 32112180.

 

  1. Pozzoli C, Bertini S, Poli E, Placenza G, Menozzi A. Relaxing effects of clenbuterol, ritodrine, salbutamol and fenoterol on the contractions of horse isolated bronchi induced by different stimuli. Res Vet Sci. 2020 Feb;128:43-48. doi: 10.1016/j.rvsc.2019.10.022. Epub 2019 Oct 31. PMID: 31710963.

 

  1. Wongwaree S, Daengsuwan T. Comparison efficacy of randomized nebulized magnesium sulfate and ipratropium bromide/fenoterol in children with moderate to severe asthma exacerbation. Asian Pac J Allergy Immunol. 2019 Aug 18. doi: 10.12932/AP-190717-0118. Epub ahead of print. PMID: 31421659.

 

  1. Omar MA, Hammad MA, Awad M. Utility of Europium ion characteristic peak for quantitation of Fenoterol hydrobromide and Salmeterol xinafoate in different matrices; application to stability studies. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jun 15;217:182-189. doi: 10.1016/j.saa.2019.03.072. Epub 2019 Mar 25. PMID: 30933783.

 

  1. Stoiber B, Haslinger C, Schäffer MK, Zimmermann R, Schäffer L. Effect of dual tocolysis with fenoterol and atosiban in human myometrium. J Perinat Med. 2019 Feb 25;47(2):190-194. doi: 10.1515/jpm-2018-0010. PMID: 30218606.

 

Products are for research use only. Not for human use.

 

 

 

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed