ALK2-IN-2


Catalog No. size PriceQuantity
M6913-2 2mg solid $156
M6913-10 10mg solid $652

Description

Cas:2254409-25-9

Product Information:

ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3.

 

IC50 & TargetALK2  9 nM (IC50)

 

Molecular Weight497.61

 

FormulaC₂₈H₂₇N₅O₂S

 

Smiles

CC(N1CCCC1)C(C=C2)=CC=C2C(C=N3)=CN4C3=C(C5=CC=C(S(=O)(N)=O)C6=C5C=CC=C6)C=N4

 

Shipping

Room temperature in continental US; may vary elsewhere.

 

Storage

Powder     -20°C   3 years

4°C   2 years

In solvent -80°C   6 months

-20°C   1 month

 

 

References

 

  1. Jiang JK, et al. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3356-3362.

 

Products are for research use only. Not for human use.

 

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